Association between HCV infection and the incidence of Diabetes Mellitus in Egyptians
El-Bolkiny, Y., Harras, F., Mansour, M., Alkhazendar, A., Raghaey, M. (2019). Association between HCV infection and the incidence of Diabetes Mellitus in Egyptians. EKB Journal Management System, 3(1), 21-30. doi: 10.21608/jcbr.2019.37766
Yousry E El-Bolkiny; Fuad K Harras; Merveet A Mansour; Abdelhalim A Alkhazendar; Mohamed Raghaey. "Association between HCV infection and the incidence of Diabetes Mellitus in Egyptians". EKB Journal Management System, 3, 1, 2019, 21-30. doi: 10.21608/jcbr.2019.37766
El-Bolkiny, Y., Harras, F., Mansour, M., Alkhazendar, A., Raghaey, M. (2019). 'Association between HCV infection and the incidence of Diabetes Mellitus in Egyptians', EKB Journal Management System, 3(1), pp. 21-30. doi: 10.21608/jcbr.2019.37766
El-Bolkiny, Y., Harras, F., Mansour, M., Alkhazendar, A., Raghaey, M. Association between HCV infection and the incidence of Diabetes Mellitus in Egyptians. EKB Journal Management System, 2019; 3(1): 21-30. doi: 10.21608/jcbr.2019.37766

Association between HCV infection and the incidence of Diabetes Mellitus in Egyptians

Egyptian Journal of Cancer and Biomedical Research
Article 4, Volume 3, Issue 1 - Serial Number 4, April 2019, Pages 21-30    PDF (1.03 M)
Document Type: Original Article
DOI: 10.21608/jcbr.2019.37766
Authors
Yousry E El-Bolkiny* 1; Fuad K Harras2; Merveet A Mansour3; Abdelhalim A Alkhazendar3; Mohamed Raghaey4
1Department of Zoology, Faculty of Science, Tanta University, Egypt
2Internal Medicine Department, Faculty of Medicine, Tanta University, Tanta, Egypt
3Zoology Department, Faculty of Science, Tanta University, Tanta, Egypt
4Internal Medicine Department, Faculty of Medicine, Al-Azhar University, Cairo, Egypt
Abstract
The present work was planned to find a correlation between HCV infection and diabetes mellitus (DM) incidence in Egyptian patients by finding a possible relationship between HCV antibodies and both anti-insulin antibodies (AIAs) and pancreatic islet cell antibodies (PICAs). The screening results showed that the percentage of HCV patients out of 200 subjects were 35.5 and 14.5% in males and females, respectively. Also, the association between DM and HCV were 13.21 and 13.64% in men and women, respectively. The titers of antibodies in diabetic or non-diabetic patients ranged from 30 - 58 for AIAs and from 30 - 40 for PICAs, The percentage of patients with raised serum transaminases was significantly more in DM patients with positive HCV antibody (52.3%) than DM patients with negative HCV antibody (16.7%). Conclusion, it can be concluded that diabetic or non-diabetic patients with HCV might have a rise titer of the antibodies toward insulin or its secretory cells in pancreas or toward both. where are more susceptible to both HCV-infection and antibodies than women, indicating to here is a significant association between HCV infection and induction of diabetes in Egyptians.
Keywords
HCV; Anti-insulin antibodies; Diabetes mellitus
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