The potential therapeutic effect of loaded ginger nanoparticles against Ehrlich ascites carcinoma (EAC) bearing mice-induced renal toxicity | ||||
| Delta Journal of Science | ||||
| Volume 48, Issue 2, August 2024, Page 142-160 PDF (964.87 K) | ||||
| Document Type: Research and Reference | ||||
| DOI: 10.21608/djs.2024.310411.1180 | ||||
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| Authors | ||||
Mona Mohammed Elwan   1; Mai abdelkarim elserafy2; Ola Mohamed elborady3; ahmed massoud4; Ahlam aboushafei4
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| 1Histology, Zoology Department, faculty of science, Tanta University | ||||
| 2Zoology Department, faculty of science, Tanta University | ||||
| 3Institute of Nanoscience and Nanotechnology, Kafrelsheikh University, 33516, Kafr ElSheikh, Egypt. | ||||
| 4Zoology department, faculty of science, Tanta university, Tanta, Egypt | ||||
| Abstract | ||||
| Ehrlich ascites carcinoma (EAC) are undifferentiated, natural mouse mammary adenocarcinomas that are primarily used for research. The current study aims to assess whether loaded ginger nanoparticles have a protective effect against renal toxicity induced by EAC in mice. This study employed forty-nine mice, which were separated into seven groups as follows: Group1(GR1) was utilized as the negative control. EACs were implanted in GR2 mice. The GR3 was treated with Cis (40 μg/mouse) on the first day post-inoculation. The fourth, fifth, and sixth treatment groups received Gin, AGNPS, and Gin/AGNPS (0.4 mg/mouse for 6 days). The seventh treated group was injected with Cis (40 μg/mice) and then administered with Gin/AGNPS for 6 days. All mice were slaughtered to examine the biochemical, histological and immunohistochemical alterations in the kidney. The findings demonstrated a substantial increase in the EAC group's overall body weight. However, in contrast to (GR2), groups that received Cis, AGNPS, Gin, Gin/AGNPS, and Cis/Gin/AGNPS displayed a small percentage increase in body weight. Furthermore, EAC produced renal impairment, as demonstrated by increase in serum urea and creatinine levels. While the treatment group with Gin/AGNPS and Cis/Gin/AGNPS improved and reduced these differences in renal function stress. Histological and immunohistochemical staining verified these results. Present results imply that loaded ginger nanoparticles may possess anti-oxidant, anti-cancer, and renal protective qualities in addition to inhibiting the damage that EAC causes to the kidney dysfunction. | ||||
| Keywords | ||||
| Ehrlich ascites carcinoma (EAC); histopathological; immunohistochemical; ginger nanoparticles; renal toxicity; Cisplatin (Cis) | ||||
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