The Potential Ameliorative role of wheat germ oil on sub chronic cadmium chloride induced hepato-renal toxicity in adult male albino rats | ||
| Zagazig University Medical Journal | ||
| Volume 31, Issue 1, January 2025, Pages 143-164 PDF (2.41 M) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/zumj.2024.308820.3500 | ||
| Authors | ||
| Hanan Mohamed Ahmed Hassanein1; Yara Mohamed Medhat Abd-elrazek Elfakharany1; Nehad Fahmy Mazen2; Alaa Ramadan Mahmoud Elsa Nafae* 1; Marwa AbdEl-Moniem Amer1 | ||
| 1Forensic Medicine and Clinical Toxicology Department, Faculty of Medicine, Zagazig University | ||
| 2Medical Histology and Cell Biology Department, Faculty of Medicine, Zagazig University, Egypt | ||
| Abstract | ||
| Background: Cadmium (Cd) is a hazardous non-essential transition metal that can be harmful to both human and animal health. Wheat germ oil (WGO) is a by-product of the milling of grain into flour which believed to have anti-oxidant properties contributing its protective effect against different toxins. So we aimed to study toxic effects of cadmium on liver and kidneys in adult male albino rats and to evaluate protective effect of wheat germ oil against these toxicities through biochemical, histopathological and PCR studies. Methods: The study was conducted on 50 adult male albino rats, divided into: negative control group received regular diet and tap water; positive control group received 0.25 ml corn oil; cadmium group received 3.5 mg/kg CdCl2 daily; a WGO group received 100 mg/kg WGO daily; and combined Cd + WGO group for 12 weeks. Blood samples and target organs were collected for biochemical, gene expression and histopathological studies. Results: Cadmium administration significantly elevated levels of ALT, AST, ALP, LDH, bilirubin, urea and creatinine while decreasing total proteins, albumin. Cd increased Bax, Caspase-3 and TNF-α and decreased Bcl-2 and IL-10 gene expression. Histopathological studies revealed that cadmium exposure caused hepatic and renal damage. Co-administration of WGO resulted in moderate improvement. Conclusion: Cadmium exposure causes significant biochemical and histopathological damage to liver and kidneys. WGO administration significantly ameliorated biochemical parameters and histopathological findings, indicating its potential as a protective agent in reducing cadmium toxicity. | ||
| Keywords | ||
| Wheat germ oil; Subchronic cadmium chloride; induced hepato-renal toxicity; Adult male albino rats | ||
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