EVALUATION OF THE POTENTIAL ANTI-CARCINOGENIC EFFECT OF ETHANOLIC CAPPARIS SPINOSA L. LEAVES EXTRACT ON ORAL SQUAMOUS CELL CARCINOMA CELL LINE (SCC-4) | ||||
| Alexandria Dental Journal | ||||
| Article 6, Volume 50, Issue 2, August 2025, Page 38-44 PDF (399.46 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/adjalexu.2023.247088.1438 | ||||
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| Authors | ||||
Wafa Mokhtar Awedat  1; Sahar Abbas El-barrawy2; Salama Mohamed El-Darier3; Ashraf Khaled Awaad4; Mai Mahmoud Saleh5
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| 1Lecturer of Oral Pathology, Faculty of Dentistry, Garian University, Libya | ||||
| 2Professor of Oral Pathology, Oral Pathology Department, Faculty of Dentistry, Alexandria University, Alexandria, Egypt | ||||
| 3Professor of Botany, Botany and Microbiology Department, Faculty of Science, Alexandria University, Alexandria, Egypt | ||||
| 4Researcher of Biochemistry and Molecular Biology, Center of Excellence for Research in Regenerative Medicine and its Applications (CERRMA)Faculty of Medicine, Alexandria University | ||||
| 5Lecturer of Oral Pathology, Oral Pathology Department, Faculty of Dentistry, Alexandria University, Alexandria, Egypt. | ||||
| Abstract | ||||
| INTRODUCTION: Malignancy is regarded as a potentially fatal disorder that can impact human health globally. More than 90% of all oral cavity malignancies that have been detected are invasive oral squamous cell carcinomas (OSCCs). Patients having OSCC still have an extremely poor survival rate, even though medical therapy has advanced significantly. Medicinal plants have been the subject of recent scientific research. Capparis spinosa L. (CS) is among the prominent plants found across the Mediterranean region. According to phytochemical analysis, CS leaves are considered to be a promising therapeutic plant since they are an essential spring of bioactive substances such as flavonoids and phenolic acids. Research has indicated that CS extract exhibits anti-carcinogenic properties against numerous forms of cancer. OBJECTIVE: The current research was to the evaluation of the anti-carcinogenic effect of the ethanolic extract of CS leaves on SCC-4 cell lines contrasted with both the untreated cancer cell lines and Cisplatin treated. MATERIALS AND METHODS: This work comprised an in vitro investigation. SCC-4 cell line was separated into 3 groups: group 1 was considered as negative control (untreated), group 2 was positive control (Cisplatin-treated), and group 3 (treated with CS leaves extract). Viability, proliferation and apoptosis assays were performed to evaluate the possible therapeutic effect of the CS leaves extract in duration of 48 hours. RESULTS: Treating SCC-4 cell line with the extract of CS leaves has shown that the viability effect was in a dose-dependent fashion. The IC50 or the half-maximal inhibitory concentration was equal to 176.3µg/ml. | ||||
| Keywords | ||||
| Oral squamous cell carcinoma; Capparis spinosa L; Viability; Proliferation; Apoptosis | ||||
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