Searching for a Cheap Marker for Placenta Accreta Spectrum in a Low Resource Country: A Prospective Cohort Study | ||||
| The Egyptian Journal of Fertility and Sterility | ||||
| Article 4, Volume 28, Issue 4 - Serial Number 11106352, July 2024, Page 24-33 PDF (3.34 MB) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/egyfs.2024.378190 | ||||
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| Authors | ||||
Ahmed Sherif Abdel Hamid   1; Hazem El Zeneiny* 2; Amira Al Nahas* 3, 4
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| 1Assistant professor of Obstetrics & Gynecology, Faculty of Medicine, Ain Shams University Cairo, Egypt | ||||
| 2Professor of Obstetrics & Gynecology, Faculty of Medicine, Ain Shams University, Cairo, Egypt | ||||
| 3Department of Obstetrics & Gynecology, Faculty of Medicine, Ain Shams University, Cairo, Egypt | ||||
| 4Lecturer of Obstetrics & Gynecology, Faculty of Medicine, Ain Shams University Cairo, Egypt | ||||
| Abstract | ||||
| Abstract Objective: To assess maternal serum amyloid A (SAA) levels among women with Placenta Accreta spectrum. Methods: We performed a prospective observational cohort study among women with Placenta Accreta Spectrum at Ain Shams University Maternity Hospital, Cairo, Egypt, between March 2017 and August 2017. The study group included women with a previous CS and diagnosed with placenta previa or accreta (20 patients in each group), while the control group included twenty women with a normally situated placenta. We collected Serum samples to measure SAA levels at the time of admission. The primary outcome was the association between SAA and the Placenta Accreta Spectrum. SAA levels were compared using the ANOVA test. We also performed Receiver Operating Characteristics characteristic analysis for previa/accrete versus normal and previa versus accreta. Results : Each group contained 20 participants with comparable baseline characteristics. The Maternal serum amyloid-A level was 19.9±5.0 μg/mL, 18.3±5.5 μg/mL in the previa and accreta groups versus 11.4±2.1 μg/mL in the control group (P<0.001). The ROC analysis was significantly lowest among the normal group with no significant difference between the previa and accrete groups. Maternal serum amyloid-A had significantly high diagnostic performance in differentiating previa and/or accreta groups from the normal group and low non-significant diagnostic performance in determining previa from accreta groups. Conclusion: Maternal SAA levels are increased in women with Placenta Accreta Spectrum. | ||||
| Keywords | ||||
| Keywords: Serum amyloid A; Placenta Accreta Spectrum; Morbid adherent placenta; biochemical marker. | ||||
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