Unsafe sexual practices prior to incarceration, and early childhood transmission are potential high-risk factors of Hepatitis B and HIV infection among prisoners in Blantyre, Malawi.

Chimberenga, Shakira; Phiri, Vincent Samuel; Mgawa, Anastansia; James, Grace; Jumbe, Enock; Van Hout, Marie-Claire; Nyirenda, Mulinda; Shawa, Isaac Thom

doi:10.21608/mid.2024.308772.2121

	Unsafe sexual practices prior to incarceration, and early childhood transmission are potential high-risk factors of Hepatitis B and HIV infection among prisoners in Blantyre, Malawi.
Microbes and Infectious Diseases
Article 10, Volume 6, Issue 1, February 2025, Page 110-122 PDF (314.56 K)
Document Type: Original Article
DOI: 10.21608/mid.2024.308772.2121
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Authors
Shakira Chimberenga¹^{, 2}; Vincent Samuel Phiri ¹; Anastansia Mgawa¹; Grace James³; Enock Jumbe³; Marie-Claire Van Hout ⁴; Mulinda Nyirenda ¹^{, 5}; Isaac Thom Shawa ¹^{, 6}
¹Kamuzu University of Health Sciences, P/Bag 360, Chichiri Blantyre 3, Malawi.
²Ministry of Health, Mzuzu Central Hospital, P.O. Box 209, Mzuzu, Malawi
³Johns Hopkins Research Project, P.O. Box 1131, Blantyre, Malawi.
⁴VP Research, Innovation and Impact, South East Technological University, WaterfordCork Road Campus, X91 K0EK, Ireland.
⁵Ministry of Health, Queen Elizabeth Central Hospital, P.O. Box 95, Blantyre, Malawi
⁶University of Derby, Department of Biomedical and Forensic Sciences, Kedleston Road campus, Derby, DE22 1GB, United Kingdom.
Abstract
Background: Hepatitis B and C viruses (HBV/HCV) are the major causes of liver diseases primarily transmitted through contact with infected blood, and body fluids. Prison settings are a significant driver of blood-borne viruses among prisoners during detention and after release. Aim: The primary aim of this study was to assess the prevalence of HBV, HCV and HIV among those detained at Chichiri prison. Methods: The study enrolled 220 participants [86.4% males (n=190/220), 13.6% females (n=30/220) at Chichiri prison. A structured questionnaire was used for collection of demographic details, assessment of knowledge, and risk factors for transmission of viral hepatitis in prison environment in Malawi. Serum samples were prepared and analyzed utilizing HBV, and HCV rapid assays. All positive samples were run on sandwich enzyme immunoassay (EIA). Results: The HBV prevalence was estimated at 8.6%; whereas HCV was not detected in the sample (0%). The HIV prevalence rate was 21%, and HBV/HIV co-infection prevalence was 11%. The majority (79.1%) of prisoners were incarcerated between 2017 and 2020. HBV/HIV co-infection was observed in 11% of the sample. Conclusion: This study confirms high prevalence of HBV among prisoners at Chichiri. Findings suggest that intra-prison viral hepatitis transmission was very minimal, possibly due to criminalisation of high-risk practices (injecting drug use, sex between men) for exposure to blood-borne viruses. Sexual transmission prior to incarceration was the highest risk factor for viral hepatitis and HIV. Prison environments present both challenges and opportunities for prevention and treatment of viral hepatitis and HIV infections.
Keywords
Prisoners; Inmates; Prevalence; Blood-borne viral infections; Blantyre Malawi


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