ANTIOXIDANT , HEPATORENAL AND MUTAGENIC EFFECTS OF BUTYLATED HYDROXYTOLUENE | ||||
| Veterinary Medical Journal (Giza) | ||||
| Volume 55, Issue 1, January 2007, Page 101-113 PDF (4.16 MB) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/vmjg.2007.378395 | ||||
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| Authors | ||||
| ATTA H* 1; HASHIM M1; ARBID S2; SOMAIA NADA3; MRRGAN A3; GIHAN ASAAD2 | ||||
| 1Pharmacology and Toxicology and Forensic Medicine Departments, Faculty of Veterinary Medicine, | ||||
| 2National Research Center, Dokki, Egypt | ||||
| 3Pharmacology and Toxicology and Forensic Medicine Departments, Faculty of Veterinary Medicine, Cairo University | ||||
| Abstract | ||||
| The antioxidants, biochemical, and mutagenic effects of butylated hydroxytoluene (BHT) in doses of 3 and 30 mg/kg b.wt. were studied in normal and CC14-intoxicated rats. The oral LD59 of BHT in rats was 1740 mg/kg b.wt. No significant changes of almost all of the studied serum and tissue parameters including bone marrow cells compared to the control groups indicating the safety of this compound. CCI4- intoxicated animals showed significant elevations in serum alanine aminotransferases (ALT), aspartate aminotransferases (AST) and alkaline phosphatase (AP) activities. serum bilirubin, cholesterol, creatinine, urea and tissue lipid peroxides (LP) concentrations. In contrast, significant reduction was observed in tissue reduced glutathione concentration (GSH). Oral administration of BHT concurrently with CCl4 for 4 weeks significantly returned all the biochemical parameters to toward their normal values confirming safety and excellent antioxidant effect of BHT. | ||||
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