Assessment of C-peptide In Cord Blood of Neonates of Diabetic Mothers

Kamal, Hossam Mostafa; Mohammed, Aya Mohammed Abdelmageed; Kamel, Alia Talaat Ahmed; El gebaly, Sherief Mohammed

doi:10.21608/zumj.2024.310462.3507

	Assessment of C-peptide In Cord Blood of Neonates of Diabetic Mothers
Zagazig University Medical Journal
Article 16, Volume 30, Issue 8, November 2024, Page 4423-4433 PDF (437.32 K)
Document Type: Original Article
DOI: 10.21608/zumj.2024.310462.3507
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Authors
Hossam Mostafa Kamal¹; Aya Mohammed Abdelmageed Mohammed ²; Alia Talaat Ahmed Kamel³; Sherief Mohammed El gebaly⁴
¹Professor of Pediatrics, Faculty of Medicine, Zagazig University
²Resident of Pediatrics, Al Ahrar Teaching Hospital, Zagazig
³Lecturer of Biochemistry, Faculty of Medicine, Zagazig University
⁴Assistant professor of Pediatrics Faculty of Medicine, Zagazig University
Abstract
Background: Understanding how C-peptide levels in the umbilical cord can be used to predict when a diabetic mother's newborn will experience hypoglycemia is urgently needed. This study aimed to assess the role of umbilical cord C-peptide levels in the early prediction of hypoglycemia among neonates of diabetic mothers. Methods: We carried out this cross-sectional study on 52 singleton newborns born to diabetic mothers in the neonatal resuscitation room and obstetric operation room at Zagazig University Hospital. The umbilical cord C-peptide concentration was assessed via an enzyme-linked immunosorbent assay. complete blood count, blood glucose level, insulin level, and glycated hemoglobin (HbA1C), were performed for neonates and mothers. Neonatal blood glucose was measured hourly three times. Results: A significant association was found between neonatal C-peptide levels and maternal premature rupture of membranes (p=0.013). Compared to normoglycemic neonates, hypoglycemic neonates had significantly higher C peptide levels (p<0.001). The best cut-off value of neonatal C-peptide for the prediction of neonatal hypoglycemia is ≥0.3685 ng/ml, with an area under the curve of 0.963, a sensitivity of 88.9%, a specificity of 88.4%, a positive predictive value of 61.5%, a negative predictive value of 97.4%, and accuracy of 88.5% (p<0.001). Conclusion: This study underscores the importance of monitoring umbilical cord C-peptide levels as a potential early predictor of neonatal hypoglycemia among infants born to diabetic mothers.
Keywords
Umbilical Cord; C-peptide; Neonate; infant of diabetic mother


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