Long-Term Use of Proton Pump Inhibitors Increases the Risk of Renal Diseases | ||
| Azhar International Journal of Pharmaceutical and Medical Sciences | ||
| Article 1, Volume 5, Issue 1, January 2025, Pages 1-16 PDF (373.72 K) | ||
| Document Type: Review Articles | ||
| DOI: 10.21608/aijpms.2024.378587 | ||
| Authors | ||
| Amira Fayed* 1; Eman A Mohamed2; Aya M Shaheen3; Amany Balah2 | ||
| 1Department of Pharmacology and Toxicology, Faculty of Pharmacy, Egyptian Russian University, Cairo, Egypt | ||
| 2Department of Pharmacology and Toxicology, Faculty of Pharmacy (Girls), Al-Azhar University, Cairo, Egypt | ||
| 3Department of Pharmacology and Toxicology, Faculty of Pharmacy, Egyptian Russian University, Cairo, Egypt | ||
| Abstract | ||
| Proton pump inhibitors (PPIs) are drugs that successfully inhibit stomach acid secretion. It is used for the management of various acid-related conditions, including gastroesophageal reflux disease (GERD) and other gastric illnesses. It can reduce hydrochloric acid output via irreversible binding to the hydrogen potassium adenosine triphosphatase (H+/K+ ATPase) and inhibiting its action in the stomach. PPIs are among the most often prescribed drugs, however, 25% to 70% of these prescriptions have no legitimate indication. As a result, patients frequently take these treatments without benefit exposing themselves to unwanted adverse events. PPIs can cause acute interstitial nephritis (AIN), which can be a serious side effect associated with acute kidney injury (AKI). It has been reported that using PPIs for a long time has been associated with an elevated risk of chronic kidney disease (CKD). As a result, this review aims to investigate the adverse effects of long-term use of PPIs on renal function | ||
| Keywords | ||
| Proton pump inhibitors; acute kidney injury; chronic kidney disease; acute interstitial nephritis; adverse effects | ||
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