Tim-4 an emerging immune modulatory molecule | ||
| Journal of Current Veterinary Research | ||
| Article 9, Volume 10, Issue 1, 2016, Pages 64-71 | ||
| Document Type: Original Article | ||
| DOI: 10.21608/jcvr.2016.37887 | ||
| Author | ||
| Alaa E.H. Mostafa* | ||
| Dean of faculty of veterinary medicine, Sadat university | ||
| Abstract | ||
| Tim-4 is a member of the T-cell immunoglobulin mucin (Tim) family of proteins that has been implicated in the control of T cell-mediated immune responses. Tim-4 that is expressed on various macrophages subsets has been recognized as a phosphatidylserine receptor mediating phagocytosis of apoptic cells by peritoneal macrophages. The functions of Tim-4 in immune responses, however, are still unclear. In this study, results showed that blocking of Tim-4 that is preferentially expressed on F4/80+ peritoneal macrophages results in increased C04+ T cells proliferation. Additionally the administration of anti-Tim4 monoclonal antibody decreased the percentage of Foxp3+CD4+CD25+ T-regulatory cells in lymph nodes of immunized mice suggesting an emerging role of Tim-4 molecule in immune regulation as a promising target for treatment and prevention of autoimmune diseases. | ||
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