PREPARATION AND EVALUATION OF KILLED NDV VACCINE USING NEW OIL ADJUVANT | ||||
| Veterinary Medical Journal (Giza) | ||||
| Volume 56, Issue 2, April 2008, Page 95-104 PDF (3.05 MB) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/vmjg.2008.378938 | ||||
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| Authors | ||||
| NADA FATEHY* 1; SABER S2; REDA M2; AFAF AMIN1; SUZAN EL-MAHDY3 | ||||
| 1Veterinary Serum and Vaccine Research Institute | ||||
| 2Faculty of Vet. Medicine, Cairo Uni. | ||||
| 3Central laboratory for Quality Control and Evaluation of Vaccines P.O.Box 131, Abbasia, Cairo, Egypt. | ||||
| Abstract | ||||
| Preparation of inactivated oil Newcastle disease virus (NDV) vaccine using different new oil adjuvants Montonide ISA 70 VG, ISA 763A VG and ISA 775 as oil adjuvants in comparison with paraffin oil was carried out. The prepared vaccines with Montanide ISA 70 VG, 763 A VG and 775 VG induced high antibody titers than that induced by vaccines prepared with paraffin oil when determined by serological tests (HI and SNT). The highest titer observed in prepared vaccine by ISA 70 VG oil adjuvant after 3 weeks post vaccination and remained high till 12 weeks post vaccination and has long duration of immunity reached to 12 month with a protective antibody titer and protection against challenge while prepared vaccine by Montonide ISA 763 A VG oil adjuvant reached 10 month with Montanide ISA 775 reached to 9 months, but in paraffin protective antibody titer reached only till 5 month. | ||||
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