The Anti-Diabetic, Lipidemic, And Pro-Inflammatory Effects of oral hypoglycemic on T2DM Obese Patients | ||||
| Egyptian Journal of Chemistry | ||||
| Volume 68, Issue 4, April 2025, Page 91-101 PDF (959.27 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/ejchem.2024.310327.10156 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
Naglaa Hamdy 1; Mohamed Abdel-Gabbar 2; Hader I Sakr  3; Safi Salah Gaber 4; Mohamed Kandeal5; Ayman M. Abdel-Aziz 6; Osama Ahmed7
| ||||
| 1Biochemistry department, Faculty of Science, Beni-Suef University. Beni Suef, Egypt. | ||||
| 2Biochemistry Department, Faculty of Science, Faculty of Science, Beni-Suef University, Beni-Suef 62521, Egypt. | ||||
| 3Al-Manyal Cairo | ||||
| 4Department of Medical Physiology, Faculty of Medicine, Beni-Suef University, Beni-Suef, Egypt. | ||||
| 5Biochemistry Department, Faculty of Veterinary Medicine, Beni-Suef University, Beni-Suef 62521, Egypt; | ||||
| 6Zoology Department, Faculty of Science, Fayoum University 63514, Fayoum, Egypt | ||||
| 7Faculty of science, Beni Suef University | ||||
| Abstract | ||||
| Background: Diabetes complications are the primary causes of DM morbidity and mortality. Objectives: comparing the anti-diabetic, lipidemic, and pro-inflammatory effects of metformin and glibenclamide in treating T2DM-obese patients, suggesting a probable novel mode of action and providing a more comprehensive understanding of T2DM pathophysiology for future therapeutic application. The effect of the adipocytokines and pro-inflammatory cytokines in T2DM was also investigated. Patients and methods: 150 subjects were allocated into five equal groups (n=30): the normal, the obese control, the obese diabetic control, the obese diabetic treated with 500 mg metformin twice daily, and the obese diabetic glibenclamide-treated, receiving 5 mg glibenclamide once daily. The blood samples were collected after six months of treatment. Results and conclusion: Metformin improved BMI, FSG, glycosylated hemoglobin, total cholesterol, and triglycerides, but it raised low-density lipoproteins and lowered high-density lipoproteins. The glibenclamide treatment significantly improved fasting insulin and C-peptide serum levels with subsequent better homeostatic model assessment for insulin resistance, but it increased BMI, TC, and TG. Visfatin and Retinol binding protein-4 showed less improvement in the glibenclamide than in the metformin-treated obese diabetic patients. In contrast, resistin decreased with glibenclamide treatment compared to metformin. The IL-1β expression was higher in the obese diabetic control and declined in the glibenclamide-treated obese diabetic patients while, IL-6, TNF-α, and IFN-γ expression decreased in metformin-treated obese diabetic patients than in glibenclamide ones. Our results also demonstrated a high positive correlation between the adipocytokines, visfatin, resistin, and RBP4 and the pro-inflammatory, cytokines IL-1β, IL-6, TNF-α and IFN-γ. From those results, treatment with metformin is recommended in the cases of obesity, inflammation, hypercholesterolemia, and hypertriglyceridemia. In addition, treatment with glibenclamide is recommended in the cases of insulin resistance and dyslipidemia. | ||||
| Keywords | ||||
| T2DM; obesity class Ⅰ; Metformin; Glibenclamide; Visfatin; Resistin; RBP-4 | ||||
|
Statistics Article View: 464 PDF Download: 196 |
||||
