Value of assessment of serum Interleukin -6 in Epileptic Patients | ||||
| Zagazig University Medical Journal | ||||
| Article 40, Volume 30, Issue 8, November 2024, Page 4717-4726 PDF (658.88 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/zumj.2024.315909.3542 | ||||
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| Authors | ||||
Mona Mohamed Amer1; Eman Ayman Abdelrheem  2; Sabah Mohamed Lotfy3; Noha Ali Hashim 4
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| 1Assistant Professor of Neurology, Faculty of Medicine, Zagazig University | ||||
| 2Resident of Neurology, Faculty of Medicine, Zagazig University | ||||
| 3Professor of Neurology, Faculty of Medicine, Zagazig university | ||||
| 4Assistant professor of Neurology, Faculty of Medicine, Zagazig university | ||||
| Abstract | ||||
| Background: The immune system has been a hotspot for epilepsy researchers during the past decade. The outcome of this is an ever-increasing body of knowledge about the role of several immunological variables in the development of epilepsy and seizures epileptogenesis. Methods: We carried out this case control study in Neurology clinic and Neurology Department, Faculty of Medicine, Zagazig University Hospitals on 224 persons categorized into two groups: 112 epileptic and 112 control. Comprehensive evaluations were conducted on all patients, including electroencephalograms, brain MRIs, standard laboratory tests, as well as serum interleukin 6 levels that were assessed by enzyme linked immunosorbent assay (ELISA). Results:Patients with epilepsy had a significantly elevated serum IL-6 level compared to the control group (p<0.001). Also, statistically significant difference was detected between drug responsive and drug non-responsive patients as regard IL-6; as mean level of IL-6 was higher among drug non-responsive patients (P=0.02), IL-6 level was significantly higher among generalized tonic-colonic seizures (P=0.02). Also, median level of IL-6 was significantly higher among patients who received polytherapy compared with patients on monotherapy (P=0.001).Median IL-6 level was significantly higher among patients who had generalized epileptiform activity (P=0.01) compared with those who had partial onset seizures. Conclusion: The correlation between serum IL-6 levels and epilepsy was statistically significant. Epileptic seizures could induce the production of IL-6 and high concentration of IL-6 could be an obvious neurotoxic and pro convulsion factor. | ||||
| Keywords | ||||
| Interleukin-6; Seizure; Refractory epilepsy; Neuroinflammation | ||||
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