Role of Biofilm Forming Staphylococcus aureus in Urinary Tract Infection | ||
| Zagazig University Medical Journal | ||
| Article 20, Volume 30, Issue 8, November 2024, Pages 4464-4475 PDF (848.96 K) | ||
| Document Type: Review Articles | ||
| DOI: 10.21608/zumj.2024.315263.3537 | ||
| Authors | ||
| Marian A Gerges1; Zahira M.F El Sayed1; Nada Ahmad Ali Gamal Eldin* 2; Manar G. Gebriel1 | ||
| 1Medical Microbiology & Immunology Department, Faculty of Medicine, Zagazig University | ||
| 2Medical Microbiology & Immunology Department, Faculty of Medicine, Zagazig University | ||
| Abstract | ||
| Background: Urinary tract infections (UTIs) are a widespread and recurring health issue that is increasingly becoming a public health concern worldwide. Each year, approximately 150 million people experience UTIs, with over half of the population reporting having had at least one UTI in their lifetime, making it one of the most prevalent bacterial infections globally. One of the main bacterial problems facing public health today is Staphylococcus aureus (S. aureus), which is most common in those suffering from urinary tract infections. While S. aureus has been linked to 0.5–6% of urinary tract infections, untreated S. aureus infections can result in serious, perhaps fatal conditions. Aim of this review article: The aim of this review is to examine how biofilm-forming S. aureus contributes to the pathogenesis of UTIs and its role in antibiotic resistance and recurrent infections. The review focuses on the mechanisms by which S. aureus biofilms exacerbate the persistence and severity of UTIs, especially in the context of multi-drug resistant strains, highlighting the challenges in treating catheter-associated urinary tract infections (CAUTI) and chronic bacterial prostatitis. Conclusion: In fact, because of its multi-drug resistant (MDR) forms, S. aureus has grown to be a global health concern. A significant contributing factor to recurrent urinary tract infections with increased resistance to antibiotics is the biofilm of S. aureus. | ||
| Keywords | ||
| Biofilm; Staphylococcus aureus; Urinary Tract Infection | ||
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