Synthesis and Biological Activity Evaluation of Some New Fused Pyrano [2,3-b] Pyridine Derivatives
Soliman, A., Shokr, E., El-Araby, A., Abdel-Aziz, A., Kamel, M., El- Remailya, M. (2024). Synthesis and Biological Activity Evaluation of Some New Fused Pyrano [2,3-b] Pyridine Derivatives. EKB Journal Management System, 9(4), 510-513. doi: 10.21608/sjsci.2024.293977.1206
Ahmed M. M. Soliman; E. Kh. Shokr; Alaa El-Araby; Ahmed E. Abdel-Aziz; Moumen S. Kamel; Mahmoud Abd El Aleem Ali Ali El- Remailya. "Synthesis and Biological Activity Evaluation of Some New Fused Pyrano [2,3-b] Pyridine Derivatives". EKB Journal Management System, 9, 4, 2024, 510-513. doi: 10.21608/sjsci.2024.293977.1206
Soliman, A., Shokr, E., El-Araby, A., Abdel-Aziz, A., Kamel, M., El- Remailya, M. (2024). 'Synthesis and Biological Activity Evaluation of Some New Fused Pyrano [2,3-b] Pyridine Derivatives', EKB Journal Management System, 9(4), pp. 510-513. doi: 10.21608/sjsci.2024.293977.1206
Soliman, A., Shokr, E., El-Araby, A., Abdel-Aziz, A., Kamel, M., El- Remailya, M. Synthesis and Biological Activity Evaluation of Some New Fused Pyrano [2,3-b] Pyridine Derivatives. EKB Journal Management System, 2024; 9(4): 510-513. doi: 10.21608/sjsci.2024.293977.1206

Synthesis and Biological Activity Evaluation of Some New Fused Pyrano [2,3-b] Pyridine Derivatives

Sohag Journal of Sciences
Volume 9, Issue 4, December 2024, Page 510-513  XML PDF (391.8 K)
Document Type: Regular Articles
DOI: 10.21608/sjsci.2024.293977.1206
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Authors
Ahmed M. M. Soliman1; E. Kh. Shokr2; Alaa El-Araby email 1; Ahmed E. Abdel-Aziz3; Moumen S. Kamel1; Mahmoud Abd El Aleem Ali Ali El- Remailyaorcid 1
1Department of Chemistry, Faculty of Science, Sohag University, Sohag, 82524 Egypt
2Department of Physics, Faculty of Science, Sohag University, Sohag 82524, Egypt
3Department of Botany and Microbiology, Faculty of Science, New Valley University, El-Kharga 72511, Egypt
Abstract
Some fused  Pyrano[2,3-b]Pyridines derivatives have been synthesized by the cyclo condensation reaction of amino cyano spiro pyrano derivative (3’-Acetyl-6'-amino-2'-methyl-2-oxospiro[indoline-3,4’- pyran]-5'-carbonitrile) with some arylidene malononitrile derivatives. The synthesized compounds have been characterized by FT-IR, NMR spectroscopy, and elemental analyses.  Newly synthesized compounds were evaluated for antimicrobial activity against filamentous and unicellular fungi Aspergillus fumigatus and Candida albicans, gram-negative bacteria Pseudomonas aeruginosa, and gram-positive bacteria Staphylococcus aureus. The synthesized compounds promise to possess high selectivity and limited side effects.  All compounds exhibited effective to moderate action against all tested microorganisms thanks to spiro heterocycles, which have a vital part in biological processes, pharmacological and therapeutic activities, and a combination of Pyran, isatin, and pyridine moieties which exhibit fungicidal, antibacterial properties, and unique, versatile molecular structure. Compound 8 was the most potent and active compound against the tested bacteria; particularly, against Staphylococcus aureus as a gram-positive bacteria with an impact (up to 90% ).
Keywords
Pyrano[2; 3-b] Pyridines; spiro pyran and antimicrobial activity
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