DINOTEFURAN INSECTICIDE EVOKES DISRUPTING OESTROUS CYCLE IN RAT FEMALE: THE AMELIORATIVE ROLE OF ROSEMARY EXTRACT | ||
| Menoufia Journal of Plant Protection | ||
| Article 8, Volume 9, Issue 8, August 2024, Pages 241-252 PDF (1.08 M) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/mjapam.2024.267101.1031 | ||
| Authors | ||
| ibrahim amar1; ragaa eissa1; samah said2; marwa gabar* 1 | ||
| 1قسم المبيدات كلية الزراعة جامعة المنوفية | ||
| 2قسم مبيدات الافات كلية الزراعة جامعة المنوفية | ||
| Abstract | ||
| Dinotefuran (DINO) is a third-generation neonicotinoid insecticide with extensive worldwide application, resulting in continued human exposure. The present study explored the reproductive toxicity of DINO on oestrous cycle stages in rat females and the ameliorative role of rosemary leaf extract (RE). Twenty rat females were exposed to DINO, RE, and their combination at 73.5 and 230 mg/kg for 14 days. The levels of estrogen and progesterone were measured, and the dysregulation of oestrous cycle stages was monitored. The exposure to DINO resulted in an imbalance in estrogen and progesterone levels. Also, the regulation of oestrous cycle stages was disrupted. These effects were mitigated when rats were administered RE. Altogether, these findings provide insights into the reproductive toxicity of DINO on rat females and the ameliorative effects of RE on DINO-induced toxicity. | ||
| Keywords | ||
| Dinotefuran; rosemary leaf extract; reproductive toxicity; pesticides | ||
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