Modulating Effect of Green Tea and Vitamin C in the Management of “Alzheimer's disease: Oxidative Stress, Cell-Based Anti-Inflammatory and Genotoxic Profiles | ||||
| Egyptian Journal of Chemistry | ||||
| Volume 68, Issue 5, May 2025, Page 489-503 PDF (2.71 MB) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/ejchem.2024.313637.10223 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
Salwa Mohamed El-hallouty 1; khaled mahmoud  2; Mahmoud Khaled Hanafy3; Eman Ayman4; Elham Mohamed Youssef 5
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| 1Drug Bioassay-Cell Culture Laboratory, Pharmacognosy Department, National Research Center (NRC), Dokki, Giza, Egypt, | ||||
| 2nrc | ||||
| 3Research Centre for Idling brain science, Department of Biochemistry, Graduate School of Medicine and pharmaceutical science, University of Toyama, 930-0194, Japan. | ||||
| 4Faculty of biotechnology, MSA university, Egypt | ||||
| 5Biochemistry Department, National Research Centre | ||||
| Abstract | ||||
| Background: Alzheimer's disease is a progressive brain disorder. Green tea (GT) and vitamin C are known for their antioxidant and anti-inflammatory properties. This study aims to investigate the potential oxidative stress, cell-based anti-inflammatory and genotoxic Profiles for synergistic effect of green tea and vitamin c against to Alzheimer's disease. Methods: In vitro assessments included their several antioxidant parameters and ability to inhibit inflammatory markers such as nitric oxide (NO), interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-α), and matrix metallopeptidase 1(MPP1) in lipopolysaccharide-activated macrophages. In vivo approach evaluated genotoxicity and their potential neurotherapy against Alzheimer's disease using a rat model. Behavioral, biochemical, and histological evaluations were conducted. Results: Green tea methanolic extract (GTME) and vitamin C showed enhanced antioxidant and anti-inflammatory modulator activities. The neurotoxicity rat’s model exhibited cognitive decline and brain injury in contrast to the control group. While treated rats with GTME and vitamin C exhibited improved cognitive function, behavior and reduced AChE levels the combination exerted a significantly more potent effect. Histological analysis confirmed improved brain tissue structure in rats receiving the combined treatment. Crucially, neither compound exhibited genotoxic properties. Conclusion: The combination of GTME and vitamin C demonstrated a promising therapeutic potential for neurodegenerative diseases due to their synergistic effects. | ||||
| Keywords | ||||
| Antioxidant; anti-inflammatory; Green tea; vitamin C; Acetylcholine esterase; Alzheimer' s Disease | ||||
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