Association between Vascular Endothelial Growth Factor Gene +405 C/G Polymorphism and Acute Coronary Syndrome | ||||
| Suez Canal University Medical Journal | ||||
| Article 2, Volume 27, Issue 3, March 2024, Page 13-22 PDF (355.31 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/scumj.2024.381128 | ||||
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| Authors | ||||
Manar H. Fathy  1; Omar M. Saleh2; Nahed Y. Abd Elrazek1; Mohamed O. Abdalla1
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| 1Department of Clinical Pathology, Faculty of Medicine, Suez Canal University, Egypt | ||||
| 2Department of Cardiology, Faculty of Medicine, Suez Canal University, Egypt. | ||||
| Abstract | ||||
| Background: Acute coronary syndrome (ACS) is an acute condition that results from decreased blood flow to the coronary arteries. According to the WHO 2020 census, 32.40% of total deaths in Egypt are due to coronary heart diseases, ranking Egypt #15 in the world. ACS is a wide spectrum including ST-segment elevation myocardial infarction, non-ST segment elevation myocardial infarction, and unstable angina. Many risk factors contribute to the etiology of ACS including lifestyle, environmental, and genetic factors. Vascular endothelial growth factor gene polymorphism is one of the genetic elements that may share in the progression of ACS. Aims: to identify the association between VEGF gene +405 C/G polymorphism and acute coronary syndrome. Methods: We designed a descriptive, case-control study. Patients were randomly recruited from March 2021 to October 2021. Fifty patients diagnosed with ACS (35 STEMI_ 10 NSTEMI_ 5 unstable angina) by laboratory tests and imaging and 50 healthy individuals, both groups were age and sex-matched. Initially, we isolated the total DNA from peripheral blood, then we investigated single nucleotide polymorphisms of VEGF (rs 2010963) and the genotyping was performed by PCR-RFLP technique. Results: Our results revealed a significant association between the +405 CC genotype (p=0.025) and acute coronary syndrome. Patients with ACS had significantly more history of diabetes mellitus in comparison with the non-ACS group (p=0.037), while regarding smoking and lipid profile, there was no statistically significant difference between the two groups. Conclusion: This study proves the existence of an association between VEGF gene polymorphisms (rs2010963) and susceptibility to ACS, so SNPs in VEGF need further investigation as prognostic markers and indicators of angiogenic potential stimulating the formation of collaterals. | ||||
| Keywords | ||||
| STEMI; NSTEMI; Atherosclerosis; risk factors; RFLP | ||||
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