Antiapoptotic effect of apigenin and vitamin E against deltamethrin induced toxicity in rats | ||
| Zagazig Journal of Pharmaceutical Sciences | ||
| Article 5, Volume 26, Issue 2, 2017, Pages 67-77 PDF (743.91 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/zjps.2017.38144 | ||
| Authors | ||
| Amany Yosry* 1; Mohamed Abd-Elaal1; Waleed Barakat2 | ||
| 11Department of Pharmacology & Toxicology, Faculty of Pharmacy, Zagazig University, Egypt | ||
| 22Department of Pharmacology & Toxicology, Faculty of Pharmacy, Tabuk University, Kingdom of Saudi Arabia | ||
| Abstract | ||
| Deltamethrin was thought to be one of the safest pyrethroid insecticides and is being used in agriculture and home appliances. Apigenin has several beneficial and pharmacological effects. It is a natural flavonoid that is found in many plants. Vitamin E, fat soluble vitamin, is a well known antioxidant and anti-inflammatory effect. The present study was performed to investigate the hepatoprotective effect of both apigenin and vitamin E against deltamethrin toxicity in rats. Administration of deltamethrin (5 mg/kg) orally for 30 days in rats revealed a significant increase in serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels while significantly decreased albumin level as compared to control rats. Furthermore, deltamethrin induced apoptotic markers including caspase-3 and first apoptosis signal receptor ligand (FAS-L). Concomitant administration of apigenin (10 or 20 mg/kg), vitamin E (100 mg/kg) or combination of both apigenin (20 mg/kg) in combination with vitamin E (100 mg/kg) for the same period normalized most of the altered biochemical parameters. These results suggest that apigenin and vitamin E administration can protect the liver from deltamethrin intoxication. | ||
| Keywords | ||
| Apigenin; apoptosis; Deltamethrin; Vitamin E; Liver damage; Liver Function Test | ||
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