BONE MARROW MESENCHYMAL STEM CELLS ALLEVIATE STREPTOZOTOCIN-INDUCED HEART DAMAGE IN RATS: A MICROSCOPIC STUDY | ||||
| Egyptian Journal of Zoology | ||||
| Articles in Press, Accepted Manuscript, Available Online from 24 September 2024 PDF (1.22 MB) | ||||
| Document Type: Original Research Papers | ||||
| DOI: 10.21608/ejz.2024.304327.1121 | ||||
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| Author | ||||
Hanan. M. Abd El-Latief 
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| Zoology Department, Women’s College for Arts, Science, and Education, Ain Shams University, Cairo, Egypt | ||||
| Abstract | ||||
| One of the most prevalent illnesses worldwide is the cardiovascular diseases. It is imperative to discover an effective natural preventive agent against myocardial injury. Changes to the amplitude and time duration of cardiac muscle contraction are among the contractility abnormalities that have been noticed in the rat heart that have diabetes produced by streptozotocin (STZ). In the current study, the possibility of bone marrow mesenchymal stem cells (BM-MSCs) to shield rats' hearts against STZ-induced cardiac injury was investigated. Three equal groups of rats were allotted: (i) the control group received a saline solution (0.9%); (ii) the STZ group received a single intraperitoneal (IP) dose of 45 mg STZ/kg of body weight; (iii) the STZ/MSCs group received one IP dose of 45 mg STZ/kg body weight and an intravenous (IV) single dose of 3×106 MSCs/rat after 8 days to induce cardiac damage. After four weeks of receiving BM-MSCs, all of the experimental rats groups were euthanized. The histology and ultrastructure of the heart were studied. Widely-spaced cardiac muscle fibres, necrotic myocytes with profoundly eosinophilic cytoplasm, and intercellular mononuclear cellular infiltration were the hallmarks of the marked pathological lesion that STZ caused. However, administration of BM-MSCs effectively mitigated the severe cardiac effects of STZ, and restored the histological and ultrastructural architecture of rats’ hearts. In conclusion, the present study demonstrated the protective potentials of BM-MSCs for reducing heart fibrosis in rats, which may be used as an adjuvant therapy for heart fibrosis. | ||||
| Keywords | ||||
| Electron microscopy; Heart damage; Light microscopy; Mesenchymal stem cells; Streptozotocin | ||||
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