Assessment of Nonalcoholic Fatty Liver Disease in Diabetic and Prediabetic Patients Using Noninvasive Methods | ||||
| Journal of Current Medical Research and Practice | ||||
| Volume 9, Issue 3, July 2024, Page 41-52 PDF (656.29 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/jcmrp.2024.295438.1074 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
Lobna Farag Eltoony; Hussein Ahmed El Amin; Lobna Abdel Wahid Ahmed; Misheal Melad Fekry  ; Mohamed Abdelhakim Mahdy
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| Department of Internal Medicine, Assiut University. | ||||
| Abstract | ||||
| Background: This study intended to evaluate the validity of hepatic steatosis and fibrosis scores to predict the existence and risk stratification of liver steatosis and fibrosis amongst diabetic, prediabetic, and non-diabetic groups. These scores include fibrosis-4 index (FIB4), nonalcoholic fatty liver disease (NAFLD) fibrosis score (NFS) for prediction of fibrosis, and hepatic steatosis index (HIS) and fatty liver index (FLI) for steatosis. Transient elastography with a controlled attenuation parameter (CAP) is a widely accepted benchmark in our research. It will also assess NAFLD occurrence in prediabetic cases. Patients and Method: This cross-sectional research was done on 150 adults who were admitted or attended the outpatient clinics of the Internal Medicine Department at Assiut University Hospital between the 1st of January 2021 and December 2021. The investigated markers' diagnostic effectiveness was evaluated using AUROC (area under the receiver operating characteristic curve). Results: Using FIB-4 at a cutoff value of 1.45 and NFS at a cutoff value of 0.67 were good predictors for detecting liver fibrosis. However, FIB-4 was more sensitive for detecting liver fibrosis, even in prediabetic individuals. Using HSI at a cutoff value of 36 and FLI at a cutoff value of 30 were good predictors for detecting liver steatosis. Conclusion: The diagnostic accuracy of the proposed scores had a dependable and acceptable value in recognizing individuals who might have severe fibrosis and/or steatosis using readily accessible clinical and laboratory data. | ||||
| Keywords | ||||
| NAFLD; Diabetic; Prediabetic; transient elastography | ||||
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