Analgesic Effect of Nalbuphine-Bupivacaine Combination in UltrasoundGuided Transversus Abdominis Plane Block in Patients Undergoing Major Abdominal Cancer Surgeries | ||||
| Journal of Current Medical Research and Practice | ||||
| Volume 9, Issue 3, July 2024, Page 81-94 PDF (858.58 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/jcmrp.2024.283499.1047 | ||||
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| Authors | ||||
Shereen Mamdouh Kamal1; Hany Ahmed Elmorabaa2; Amira Muhammed Othman  1; Rania Mohammed Abdelemam1
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| 1Department of Anesthesia, Intensive Care and Pain Management, South Egypt Cancer Institute, Assiut University. | ||||
| 2Department of Anesthesia, Intensive Care and Pain Management, Assiut University. | ||||
| Abstract | ||||
| Background: TAP block is considered a modality of pain management following major abdominal cancer surgeries. In this study, we are trying to determine whether adding nalbuphine in two different doses as bupivacaine adjunct in bilateral subcostal transversus abdominis plane block confers better post-major abdominal cancer surgery pain management. Methods: A total of ninety patients undergoing major abdominal cancer surgeries were haphazardly categorized into three groups. Group (B) obtained a TAP block with bupivacaine only, group (N10) obtained a TAP block with bupivacaine and 10 mg nalbuphine, and group (N20) obtained a TAP block with bupivacaine and 20 mg nalbuphine. The main outcome of our study was the duration until the initial request for analgesic intervention. The secondary outcomes were the quantity of morphine administered within 24 hours after the surgery, postoperative VAS scores, spirometric lung functions FEVI, FVC, and FEVI/FVC), and postoperative side effects. Results: Significant differences were observed among the three groups (B, N10, and N20) regarding the initial request for analgesia, total morphine consumption, VAS score, and respiratory function. However, no meaningful distinctions were observed between the groups regarding hemodynamics and side effects. Conclusion: Nalbuphine added to bupivacaine in TAP block has advantages over bupivacaine, only more pain relief, less analgesic request, and less total amount of morphine in patients undergoing cancer abdominal surgeries in a dose-dependent manner. | ||||
| Keywords | ||||
| Post-operative; Pain; Opioids. | ||||
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