Healing Effect of Topically Applied Nano-Curcumin on Buccal Traumatic Ulcer in Albino Rats (Histological and Immunohistochemical study) | ||
| Egyptian Dental Journal | ||
| Volume 70, Issue 4 - Serial Number 3, October 2024, Pages 3225-3240 PDF (4.57 M) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/edj.2024.294541.3069 | ||
| Authors | ||
| Rasha Mohamed Taha* 1; Waffa Hassanein El-Hossary2; Waleed Mohamed Shaker3 | ||
| 1Associate Professor, Oral Biology Department Faculty of Dentistry, Suez Canal University | ||
| 2Associate Professor, Oral and Maxillofacial Pathology, Faculty of Dentistry, Suez Canal University | ||
| 3Assistant Professor, Faculty of Dentistry, South Valley University | ||
| Abstract | ||
| Background Curcumin have numerous biological advantages, such as antioxidant, anti-inflammatory and antimicrobial properties. However, its practical application is hindered by low solubility and short plasma half-life. Therefore, this study seeks to evaluate the impact of topically administered Nano-curcumin on the healing of induced traumatic ulcers in the buccal mucosa of albino rats. Material and methods: Fifty-four adult albino rats were assigned to five groups. The negative control group (n=12) received no ulcer induction or treatment and was euthanized at two time points: on the 7th day and the 14th day. 2-Positive control group: (n=6), buccal traumatic ulcers were induced, and the rats were euthanized after 2 hours. 3-Self-healing group: (n=12), induction of traumatic ulcer in buccal mucosa of rats, then euthanization after 7th and 14th days (6 rats for each intervals) for self-healing evaluation. 4-Curcumin treated group: (n=12), induction of buccal traumatic ulcer, curcumin gel was topically applied on ulcer twice daily, euthanization after 7th and 14th days (6 rats for each intervals). Nano-Curcumin group: (n=12), induction of buccal traumatic ulcer, Nano-curcumin emulsion was topically applied on ulcer twice daily, euthanization after 7th and 14th days (6 rats for each intervals). Ulcer healing was evaluated by Histopathological and immuno-histochemical assessments for TGF-βII and E-Cadherin. Results: Nano-Curcumin treated group indicating potential for ulcer healing histopathologically and immuno-histochemically compared to other studying groups in albino rates. Conclusion: Nano-curcumin represent effective alternative to conventional medication and has superiority on curcumin regarding the acceleration of ulcer healing due to better solubility and enhanced Nano-properties. | ||
| Keywords | ||
| Curcumin; Nano Particles; Wound Healing; TGF-β; E-cadherin | ||
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