Evaluation of Glutathione Peroxidase (GPx) and Superoxide Dismutase (SOD) salivary levels in Oral Lichen Planus patients, Diabetics, and Diabetics with Oral Lichen Planus | ||
| Egyptian Dental Journal | ||
| Volume 70, Issue 4 - Serial Number 3, October 2024, Pages 3267-3280 PDF (555.43 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/edj.2024.299857.3093 | ||
| Authors | ||
| Yasmine Kamal* 1; olfat Gamil shaker2; Heba Nader Shalash3 | ||
| 1Lecturer at Department of Oral Medicine and Periodontology, Faculty of Dentistry, Cairo University, Egypt | ||
| 2Professor at Department of Medical Biochemistry and Molecular Biology, Faculty of Medicine, Cairo University, Egypt | ||
| 3Researcher at Department of Basic Dental Science, Oral and Dental Research Institute, National Research Centre,Giza, and Department of Oral and Maxillofacial Pathology, Faculty of Dentistry, Galala University, Suez, Egypt | ||
| Abstract | ||
| Background: Oral lichen planus (OLP) is an autoimmune chronic muco-cutaneous disease that greatly affects the quality of life of LP patients with a progressive rate of malignant transformation. Diabetes Mellitus (DM) is assumed to be a globally affecting metabolic disorder that is exceedingly rising with a disturbing rate. Studies focusing on the association between LP and DM are still inconsistent. Objectives: This study aimed to analyze and compare the salivary levels of antioxidants GPx & SOD in the four groups of OLP, DM, OLP with DM and the healthy control, and to establish a correlation between the association of oral lichen planus with diabetes. Materials and method: 44 subjects were enrolled in this prospective cohort study. The patients were divided into four groups, 11 in each group: healthy control patients (group A), OLP (group B), DM (group C) and OLP with DM (group D). The salivary levels of antioxidants GPx &SOD were analyzed and compared to establish a correlation between the association of OLP with DM. Results: The mean GPx levels were highest in group A ,then, group C followed by group B, while group D had the lowest mean GPx level. The mean SOD levels were highest in group A followed by group C then group B while group D had the lowest mean SOD levels with insignificant difference between them. Conclusion:. Antioxidants play a vital role in human body, with a relationship existing between oxidative stress, hyperglycemia and cellular dysfunction. | ||
| Keywords | ||
| Glutathione Peroxidase (GPx); Superoxide Dismutase (SOD); Oral Lichen Planus (OLP); Diabetes; Diabetics with Oral Lichen Planus | ||
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