Role of 18F-FDG PET/CT in the Assessment of Extranodal Lesions in Patients with Lymphoma: An Observational Study | ||||
| SECI Oncology Journal | ||||
| Volume 12, Issue 3, July 2024, Page 297-307 | ||||
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| Abstract | ||||
| Background: The diagnosis and management of lymphoma require a combination of various investigations to accurately identify the subtype, stage, and prognosis of the cancer. One of the most crucial initial investigations for lymphoma is imaging studies such as computed tomography (CT) and positron emission tomography (PET) scans, which can help to identify the location, size, and extent of lymph node involvement, as well as detect any extranodal spread. Methods: This was an observational study that investigated the results and assessment of PETCT scans performed on lymphoma patients with initial extra- nodal lymphoma or extranodal involvement of advanced nodal lymphomas. This study was conducted in Assiut University Hospital, the Nuclear Medicine Unit. Results: A total of 112 patients were included in the analysis. Their median age was 40 (2-86) years and more than half of the participants (54.5%) were males. Primary extranodal disease was seen in 37.5% while secondary extranodal pattern was 62.5%. The site of the primary lesion was cervical lymph nodes in 82 (52.6%), followed by mediastinal lymph nodes in 19 (12.2%) and the rarest sites of primary lymphoma lesions were at the orbit, nose, skin, and prostate. The McNemar test was found to have a significant difference in the probability of detecting lesions between CT and PET/CT in bone marrow (P = 0.000), lung nodules (P = 0.000), mediastinal (P = 0.01) and para-aortic nodes (P = 0.006). Conclusion: PET/CT is superior to CT in detecting extranodal disease in the abdomen, especially in the spleen and liver, and BM-based osseous infiltration. PET/CT scan showed higher sensitivity, specificity, and accuracy which led to alteration of disease staging with marked effects on the decision of treatment regimens. | ||||
| Keywords | ||||
| Hodgkin lymphoma; non-Hodgkin lymphoma; PET scan; CT scan; Extranodal lesions | ||||
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