Albiflorin Alleviates Neurocognitive Impairment in L-Methionine-Induced Vascular Dementia through FoxO1/SIRT1/RANKL/BDNF Pathway
Khodir, S., Sheref, A., Omar, M., Elkholy, M., EL-Naidany, S., Bahbah, A., Hegazy, G., Bayomi, A., Mabrouk, A. (2024). Albiflorin Alleviates Neurocognitive Impairment in L-Methionine-Induced Vascular Dementia through FoxO1/SIRT1/RANKL/BDNF Pathway. EKB Journal Management System, 44(4), 236-255. doi: 10.21608/besps.2024.307702.1172
Suzan A Khodir; ALZahraa A.M Sheref; Marwa Omar; Mona S Elkholy; Sherin Sobhy EL-Naidany; Alaa Bahbah; Ghada Adel Hegazy; Asmaa l Bayomi; Anwaar Shaban Mabrouk. "Albiflorin Alleviates Neurocognitive Impairment in L-Methionine-Induced Vascular Dementia through FoxO1/SIRT1/RANKL/BDNF Pathway". EKB Journal Management System, 44, 4, 2024, 236-255. doi: 10.21608/besps.2024.307702.1172
Khodir, S., Sheref, A., Omar, M., Elkholy, M., EL-Naidany, S., Bahbah, A., Hegazy, G., Bayomi, A., Mabrouk, A. (2024). 'Albiflorin Alleviates Neurocognitive Impairment in L-Methionine-Induced Vascular Dementia through FoxO1/SIRT1/RANKL/BDNF Pathway', EKB Journal Management System, 44(4), pp. 236-255. doi: 10.21608/besps.2024.307702.1172
Khodir, S., Sheref, A., Omar, M., Elkholy, M., EL-Naidany, S., Bahbah, A., Hegazy, G., Bayomi, A., Mabrouk, A. Albiflorin Alleviates Neurocognitive Impairment in L-Methionine-Induced Vascular Dementia through FoxO1/SIRT1/RANKL/BDNF Pathway. EKB Journal Management System, 2024; 44(4): 236-255. doi: 10.21608/besps.2024.307702.1172

Albiflorin Alleviates Neurocognitive Impairment in L-Methionine-Induced Vascular Dementia through FoxO1/SIRT1/RANKL/BDNF Pathway

Bulletin of Egyptian Society for Physiological Sciences
Volume 44, Issue 4, October 2024, Pages 236-255    PDF (948.42 K)
Document Type: Review Article
DOI: 10.21608/besps.2024.307702.1172
Authors
Suzan A Khodir1; ALZahraa A.M Sheref* 1; Marwa Omar2; Mona S Elkholy3; Sherin Sobhy EL-Naidany4; Alaa Bahbah5; Ghada Adel Hegazy6; Asmaa l Bayomi7; Anwaar Shaban Mabrouk1
1Medical Physiology Department, Faculty of Medicine, Menoufia University, Shebin El-Kom, Menoufia, Egypt.
2Anatomy and Embryology Department - Faculty of Medicine, Menoufia University, Menoufia, Egypt
3Neuropsychiatry Department - Faculty of Medicine, Menoufia University, Menoufia, Egypt
4Medical Biochemistry and Molecular Biology Department, Faculty of Medicine, Menoufia University, Menoufia, Egypt
5Pathology Department - Faculty of Medicine, Menoufia University, Menoufia, Egypt
6Clinical pharmacology Department - Faculty of Medicine, Menoufia University, Menoufia, Egypt
7Zoology Department - Faculty of Science, Menoufia University, Menoufia, Egypt
Abstract
Objectives: To assess the possible neuroprotective impacts of albiflorin (ALB) on VaD induced by L-methionine (L-MET) and elucidate the potential underlying mechanisms responsible for these effects.
Background: Vascular dementia (VaD) has the second highest prevalence rate after Alzheimer’s disease. Inflammation, endothelial dysfunction, and oxidative stress are critical factors in the pathogenesis of vasodilatory disease.
Methods: A total of 30 male albino rats were separated into three groups, each involving 10 rats: Control, VaD, and VaD+ALB groups. Following the trial, the researchers assessed the rats’ cognitive function and measured many factors, including homocysteine (Hcy), superoxide dismutase (SOD), lipid profile (triglyceride levels and total cholesterol), IL-10, malondialdehyde (MDA), and TNF-α. Furthermore, the levels of forkhead box protein O1 (FoxO1), brain-derived neurotropic factor (BDNF), receptor activator of nuclear factor kappa B ligand (RANKL), and SIRT1 were evaluated using real-time PCR. The histological and immunohistochemical research of the thoracic aorta and left cerebral hemisphere involved examining eNOS, GFAB, and Bax immunoreactivity.
Results: The study revealed that L-MET administration led to the impairment of cognitive performance, a significant increase in Hcy, MDA, TNF-α, and lipid profile, and a decrease in SOD and IL-10. Moreover, it resulted in downregulating hippocampal FoxO1, SIRT1, BDNF, and eNOS immunoreaction, along with the upregulation of the RANKL gene expression and GFAB and Bax immunoreaction. ALB administration reversed the changes induced by L-MET.
Conclusion: ALB ameliorated cognitive impairment and endothelial dysfunction in VaD via its antioxidant, anti-inflammatory, and antiapoptotic effects and improved neurogenesis and gliosis via modulating the FoxO1/SIRT1/RANKL/BDNF signaling pathway.
Keywords
BDNF; FoxO1; RANKL; SIRT1; VaD
Statistics
Article View: 242
PDF Download: 188