Comparative Efficacy of Different Misoprostol Administration Routes in Medical Abortion: A Randomized Controlled Trial

Hemeda, Mohamed s; Youssef, Heba; Abdel Rahman, Abdel Rahman Z.; Abdelmottaleb, Hatem Ali Ahmed; Elyamany, Mona Ibrahim; Arafa, Ebrahim; Mohamed, Mohamed Anwar

doi:10.21608/muj.2024.321303.1186

	Comparative Efficacy of Different Misoprostol Administration Routes in Medical Abortion: A Randomized Controlled Trial
Medicine Updates
Volume 20, Issue 20, January 2025, Page 30-44 PDF (1.13 MB)
Document Type: Original Article
DOI: 10.21608/muj.2024.321303.1186
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Authors
Mohamed s Hemeda ¹; Heba Youssef¹; Abdel Rahman Z. Abdel Rahman²; Hatem Ali Ahmed Abdelmottaleb²; Mona Ibrahim Elyamany³; Ebrahim Arafa⁴; Mohamed Anwar Mohamed²
¹Department of Forensic Medicine and Clinical Toxicology, Faculty of Medicine, Port Said University, Port Said, Egypt
²Department of Forensic Medicine and Clinical Toxicology, Faculty of Medicine, Al-Azher University, Asyut, Egypt.
³Department of Forensic Medicine and Clinical Toxicology, Damietta University, Damietta, Egypt.
⁴Obstetric and genecology department, Faculty of medicine Port said university
Abstract
Background: Investigating accessible and secure procedures for medical abortion is crucial in poor nations. Misoprostol is frequently used in obstetrics and gynecology to induce abortion, prime the cervical mucosa, and perform medical abortions. This study aimed to investigate the effectiveness of various misoprostol administration methods in medical abortion. Patients and Methods: Women seeking pregnancy termination within the gestational age limit of the study were recruited and randomly assigned to one of four groups: oral, sublingual, vaginal, or buccal administrations; a sample size of 112 was planned to detect a 4-hour reduction in abortion time. Statistical analysis was performed using R software for Windows. Results: Among the various administrative groups, the success percentages differed. The groups who received the medication orally (92%), sublingually (95%), vaginally (90%), and buccally (93%) all had success rates relative to each other. Nonetheless, P> 0.05 indicated no statistically significant difference in the success rates across the groups. Conclusion: All misoprostol administration routes showed high success rates for abortion induction with minimal need for additional interventions. However, sublingual misoprostol demonstrated the most favorable profile with the lowest need for further interventions and average side effect rates.
Keywords
Misoprostol; Oral; Sublingual; Medical Abortion; Medicolegal Importance


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