Detection of toxoplasma gondii among Autoimmune Thyroid Disease (AITD) and Estimation its Association with Transforming Growth Factor-β (TGF-β) | ||||
| Egyptian Journal of Medical Microbiology | ||||
| Article 8, Volume 34, Issue 1, January 2025, Page 65-70 PDF (441.1 K) | ||||
| Document Type: New and original researches in the field of Microbiology. | ||||
| DOI: 10.21608/ejmm.2024.319415.1336 | ||||
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| Authors | ||||
Akram H. Haddad  1; Amal K. Khalaf1; Dheyaa K. Al-Waeli2
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| 1Department of Microbiology, College of Medicine, University of Thi-Qar, Thi-Qar, 6400 | ||||
| 2Department of internal medicine, College of Medicine, University of Thi-Qar, Thi- Qar, 64001 | ||||
| Abstract | ||||
| Background: Toxoplasmosis is the most common parasitic infection in the world, caused by T. gondii that is associated with a number of problems such as thyroid diseases, the most prevalent endocrine disorders secondary to diabetes. Objectives: This study aims to investigate the relationship between latent toxoplasmosis and autoimmune thyroid diseases and estimation its association with the transforming growth factor. Methodology The study included 100 patients with AITD and 70 normal control who entered Thi-Qar Specialized Diabetes, Endocrine Center in Nasiriyah city, Southern Iraq. The samples were collected during a period from August to November (2023) using ElectrochemiLuminescence and ELISA methods to determine the presence AITD and anti T.gondii (IgG) . Results: This study showed 33% of patients with AITD infected with T. gondii and the age of them ranged between15-70 years, Additionally the current study showed an association between sex of patients with AITD infected T.gondii . Also, in the present study the level of TGF among Graves' patient infected with T.gondii was (170 ± 22.8 pg/ml) compared with Graves' patient without T.gondii, it was (171 ± 18.6) while in the control group it was (213.3 ± 31.6,177 ± 22.4) respectively, TGF.β level in patients with Hashimotos thyroiditis infected with T.gondii was (145.66 ± 18.6 ) compared with Hashimotos thyroiditis without T.gondii (133.11± 28.8) while the control group was (213.3 ± 31.6,177 ± 22.4) respectively. Conclusion: The molecular mimicry hypothesis suggests a resemblance between human thyroid autoantigens and molecular components of T.gondii; the generation specific autoantibodies against thyroid. | ||||
| Keywords | ||||
| Toxoplasmosis; Autoimmune thyroid disease; ELISA; Transforming growth factor β | ||||
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