Impact of Grape Seed Extract (Proanthocyanidins) on Pathophysiological Changes and Antioxidant Capacity in Rabbit Does Expose to Heat Stress | ||
| Egyptian Journal of Veterinary Sciences | ||
| Article 33, Volume 55, Issue 7, November and December 2024, Pages 2139-2146 PDF (1 M) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/ejvs.2024.299657.2198 | ||
| Authors | ||
| emad abd allah* 1; doaa elsayed abdel hady2; Ali Elseid Ghodaia3; hany ameen4; entesar zakaria eliraqy2; zienab farouk5; sameh shedeed2 | ||
| 1cairo,nadi elsaid street, egypt | ||
| 2biotechnology, animal production research institute, agriculture research center | ||
| 3Animal Production Research Institute (APRI), Agricultural Research Center (ARC), Ministry of Agriculture, Egypt | ||
| 4sheep and goat department, animal production research institute, agriculture research center | ||
| 5biotechnology department, animal production research institute, agriculture research center | ||
| Abstract | ||
| The main aim of this study is to assess the effects of grape seed extract (GSE) on immune performance and, antioxidant capacity in rabbit does exposed to heat stress in Sakha Animal Research Station, Kafr El-Sheikh governorate, Egypt. Twenty-four healthy mature females of APRI bred were randomly allocated into 3 groups (eight rabbit does each). The first group (GI), received a regular rabbit diet and was maintained as a control group. Rabbits from the second group (G2) were treated with GSE by oral gavage at the dose of 125 mg/kg body weight. The third group (G3) of rabbits was treated with GSE by oral gavage at a dose of 250 mg/kg body weight. Rabbits were kept in cages under a constant temperature of 28-30Cº and 12:12 hour “light: dark cycle”. Food and water were provided adlibitum. The lipid parameters, Cholesterol, Triglycerides, and High-Density Lipoprotein and Low-Density Lipoprotein were determined. For biochemical and histopathological examinations specimens from liver, kidney, and ovary tissue were collected. The obtained results from in vitro data demonstrated that GSE (125-250 mg/kg) treatments increased immunosystem and decreased oxidative stress, and also suggested that GSE plays a beneficial role in the enhancement of liver and kidney function and improves the ovarian activity. | ||
| Keywords | ||
| Grape seed extract; pathophysiological changes; antioxidant capacity; heat stress; Rabbits | ||
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