Thymoquinone Protects Against Mercuric Chloride- Induced Hepatorenal Toxicity in Male Rats. | ||||
| Journal of Agricultural Chemistry and Biotechnology | ||||
| Article 2, Volume 8, Issue 1, January 2017, Page 9-14 PDF (237.15 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/jacb.2017.38412 | ||||
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| Authors | ||||
| M. EL-Sawi; M. Amer; Soad Muftah | ||||
| Zoology Department, Mansoura University, Mansoura- EGYPT | ||||
| Abstract | ||||
| The liver and kidney are imperative intentions for the toxicity of drugs, xenobiotics, thymoquinone (TQ) against mercuric chloride (HgCl2) induced hepatorenal toxicity in rats. HgCl2 at a dose of 0.02 mg/kg b w injected subcutaneously for 30 days, induced hepatotoxicity which confirmed in this study by increased activity (P ≤0.05) of liver function enzymes; CPK, whereas, serum total protein content and Na+-K+-ATPase activity were decreased significantly. Herein, HgCl2 induced also nephrotoxicity; as it induced noticeable signs of renal dysfunctions such as elevated levels (P < 0.05) of serum creatinine, blood urea nitrogen (BUN), uric acid as well as urine N-acetyl glucosaminidase (NAG) activity and total protein content. On the other hand there was a decline in the levels of urinary uric acid; creatinine and creatinine clearance. HgCl2 induced also oxidative stress in both liver and kidney tissues where reduced glutathione (GSH) content, superoxide dismutase (SOD) and catalase (CAT) activities decreased significantly; increased significantly. Additionally, TGF-β %, CD4% and CD8 % increased significantly in both liver and kidney tissues. In conclusion: Treatment of TQ concomitantly with HgCl2 ameliorates effectively the significant changes of all the tested parameters. | ||||
| Keywords | ||||
| Thymoquinone; Mercuric chloride; Hepatorenal toxicity; Rats | ||||
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