Correlation between Serum Uric Acid and Left Ventricular Hypertrophy/Left Ventricular Diastolic Dysfunction in Patients with Chronic Kidney Disease | ||||
| International Journal of Medical Arts | ||||
| Article 12, Volume 6, Issue 8, August 2024, Page 4822-4827 PDF (1.71 MB) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/ijma.2024.193411.1622 | ||||
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| Authors | ||||
Saied Abd-Elftah Amer Abo-Katella  1; Fawzy Hamed Hassan1; Ibrahim Ghounim Ramadan1; Ibrahim Faragallah Said2
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| 1Department of Internal Medicine, Faculty of Medicine, Al-Azhar University, Cairo, Egypt | ||||
| 2Department of Cardiology, Faculty of Medicine, Al-Azhar University, Cairo, Egypt | ||||
| Abstract | ||||
| Background: Serum uric acid [SUA] levels are frequently elevated in patients with chronic kidney disease [CKD]. Higher levels of SUA have been associated with cardiovascular disease. However, the direct relationship between SUA and left ventricular [LV] hypertrophy and diastolic dysfunction in CKD patients remains unclear. Aim of the work: To investigate the correlation between serum uric acid levels and LV hypertrophy as well as LV diastolic dysfunction in CKD patients with preserved LV systolic function. Patients and Methods: We studied 90 CKD patients with estimated glomerular filtration rate less than 60 ml/min/1.73 m2 and normal LV ejection fraction. Patients were divided into 3 groups according to their SUA levels: less than 10 mg/dl, 10-15 mg/dl, and more than 15 mg/dl. All patients underwent comprehensive transthoracic echocardiography including tissue Doppler imaging for the assessment of LV hypertrophy, geometry, and diastolic functions. Results: Left ventricular end-diastolic diameter, left ventricular mass index, and left atrial volume index were significantly higher in patients with SUA >15 mg/dl. Mitral peak early diastolic velocity, mitral annular early diastolic velocity, and E/e' ratio were significantly altered in patients with SUA >15 mg/dl, indicating impaired LV relaxation and increased filling pressures. Conclusion: Higher serum uric acid levels are significantly associated with increased LV hypertrophy and diastolic dysfunction in CKD patients with preserved ejection fraction. Serum uric acid may play a role in the development of cardiovascular complications in this population. | ||||
| Keywords | ||||
| Chronic Kidney Disease; Left Ventricular Hypertrophy; Uric Acid | ||||
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