Effectiveness of autologous leucocyte and platelet-rich fibrin (L-PRF) in management of chronic diabetic foot ulcers. | ||||
| The Egyptian Journal of Surgery | ||||
| Volume 43, Issue 4, October 2024, Page 1540-1547 PDF (684.01 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/EJSUR.2024.297983.1104 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
Mohamed Helal  1; Hossam Elwakeel1; Mohamed El Sorogy2; Mohammed A. Abdelmaksoud1; Mohamed S. Abdelgawad1
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| 1Department of Vascular Surgery, Faculty of Medicine, Mansoura University, Egypt | ||||
| 2Department of General Surgery, Faculty of Medicine, Mansoura University, Egypt | ||||
| Abstract | ||||
| Background: Necrotic tissues debridement, revascularization surgery, infection control, mechanical offloading, blood glucose monitoring, and patient education are the standard treatments for persistent diabetic foot ulcers. Platelet-rich fibrin has positive benefits in the stomatology fields. Leukocyte-PRF aids in soft tissue healing, bone regeneration and rich in growth factors. Aim & Objectives: This study measured changes in wound area and documented adverse events to evaluate the efficacy of L-PRF administration in the treatment of chronic diabetic foot ulcers. Patients and Methods: Twenty patients with persistent diabetic foot ulcers lasting longer than three months were enrolled in prospective quasi-experimental study. The patients' ulcers did not heal even after receiving the best possible wound care, which included appropriate offloading, daily dressing and proper control of infection. For six weeks, L-PRF applied topically to each patient once every five to seven days, either as an injectable and/or membrane form. Following each session, diameters of the ulcers were measured and recorded and carefully examined if there were any signs of infection or newly formed ulcers on the foot. Results: There was a statistically significant decrease in all three ulcer dimensions, length (p=.002), width (p=<.001),depth (p=.020) after 6 weeks and the surface area (p=<.001) . There was a statistically significant strong positive correlation between the change in ulcer length vs. the change in ulcer width and strong positive correlation between ABPI vs. The change in ulcer depth. It also shows a marginally significant negative correlation of moderate strength between the change in ulcer length vs. the hemoglobin A1c percentage and marginally significant positive correlation of moderate strength between the change in ulcer length vs. the change in ulcer depth . Conclusion: The use of L-PRF can lower the burden of the illness and greatly accelerate the healing of chronic diabetic foot ulcers. It is a speedy, affordable, and accessible modality. | ||||
| Keywords | ||||
| Diabetic foot ulcers; ankle brachial pressure index; fibrin rich in leukocytes and platelets | ||||
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