Pharmacological Potentials of the Genus Coccoloba and Its Phytochemical Constituents: An Updated Review Since 2020 | ||||
| Egyptian Journal of Chemistry | ||||
| Volume 67, Issue 12, December 2024, Page 203-216 PDF (6.12 MB) | ||||
| Document Type: Review Articles | ||||
| DOI: 10.21608/ejchem.2024.311546.10181 | ||||
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| Authors | ||||
Fatma Abdelhakim Mohamed 1; Mohammed N. A. Khalil 2; Mohamed A. Salem3; Amira Safwat El Senousy4; Ali M. El-Halawany  5
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| 1Pharmacognosy Department, Faculty of Pharmacy, Heliopolis University | ||||
| 2Pharmacognosy Department, Faulty of Pharmacy, Cairo University | ||||
| 3Pharmacognosy and natural products chemistry, Faculty of Pharmacy, Menofia University, Egypt | ||||
| 4Department of Pharmacognosy, Faculty of Pharmacy, Cairo University | ||||
| 5Pharmacognosy department, Faculty of Pharmacy, Cairo University | ||||
| Abstract | ||||
| Genus Coccoloba is the third largest genus among Family Polygonaceae (Knotweed family), comprising about 120 species. Pursuing to our exploration of various Coccoloba species, an updated mini-review about the phytochemical and biological profiling of its species is presented. It covers the scientific literature from 2020 - till now. Various biological activities were verified and assessed, e.g., antiprotozoal, smooth muscle relaxation, immunomodulatory and hepatoprotective. Phytochemical studies disclosed the presence of lignin oligomers, alkaloids and new methylated flavonoids. Some extracts were incorporated in modern pharmaceutical formulations for enhanced stability and permeability. Finally, the review explore the pitfalls of scientific literature investigating Coccoloba species. | ||||
| Keywords | ||||
| Coccoloba; Phytochemical constituents; Polygonaceae; Hepatoprotective; Smooth muscle relaxant; Immunomodulatory activity | ||||
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