Low serum DEL-1 and high serum sP-sel levels in overweight and obese Subjects and their relation to platelet count
Morad, A., eid, R., Mohie, M., muhammed, A. (2024). Low serum DEL-1 and high serum sP-sel levels in overweight and obese Subjects and their relation to platelet count. EKB Journal Management System, 4(3), 28-41. doi: 10.21608/aumj.2024.312672.1133
Amani Morad; rania eid; Mohamed Mohie; asmaa muhammed. "Low serum DEL-1 and high serum sP-sel levels in overweight and obese Subjects and their relation to platelet count". EKB Journal Management System, 4, 3, 2024, 28-41. doi: 10.21608/aumj.2024.312672.1133
Morad, A., eid, R., Mohie, M., muhammed, A. (2024). 'Low serum DEL-1 and high serum sP-sel levels in overweight and obese Subjects and their relation to platelet count', EKB Journal Management System, 4(3), pp. 28-41. doi: 10.21608/aumj.2024.312672.1133
Morad, A., eid, R., Mohie, M., muhammed, A. Low serum DEL-1 and high serum sP-sel levels in overweight and obese Subjects and their relation to platelet count. EKB Journal Management System, 2024; 4(3): 28-41. doi: 10.21608/aumj.2024.312672.1133

Low serum DEL-1 and high serum sP-sel levels in overweight and obese Subjects and their relation to platelet count

Aswan University Medical Journal
Article 4, Volume 4, Issue 3, December 2024, Page 28-41  XML PDF (933.77 K)
Document Type: Original Article
DOI: 10.21608/aumj.2024.312672.1133
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Authors
Amani Morad email orcid 1; rania eid1; Mohamed Mohie2; asmaa muhammed1
1Department of Human Physiology, Faculty of Medicine, Aswan University
2Department of Internal medicine, Faculty of medicine, Aswan University
Abstract
Obesity characterized by an elevated platelet count and hyper activation causing a pro-thrombotic state. Soluble P-selectin (sP-sel), an obesity-associated protein that enhences platelet activation, facilitates and augments thrombosis. Developmental endothelial locus-1(DEL-1) is an anti-inflammatory protein that enhances inflammation clearance; it inhibits platelet-monocyte aggregation hence thrombosis inhibition. However, serum levels of DEL-1 in obese and overweight subjects and their relation to platelet count and sP-sel have not been detected to date.
Methods: 22 controls (Group A), 22 overweight subjects (Group B), and 22 obese subjects (Group C) were enrolled in this case-control study. Serum levels of PLC, MPV, RBCs, HB, WBCs, Lymphocyte count, sP-sel, and DEL-1 were measured.
Results: levels of HB, DEL-1, and RBCs were lowest in group (C) and highest in group (A) with a statistically significant difference between these two groups. While, PLC,MPV, WBCs, lymphocyte count, and sP-sel levels were highest in group (C) and lowest in group (A). BMI, platelets, and WBCs count correlated positively with sP-sel and negatively with DEL-1 levels. sP-sel and DEL-1 showed a negative correlation with each other.
Conclusion: Increased sP-sel and decreased DEL-1 levels in overweight and obese might have a role in raising thrombosis risk and inflammation in these subjects.
Keywords
Keywords: Developmental Endothelial Locus-1; Obesity; Platelet Count; Soluble P-selectin; Thrombosis
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