Low serum DEL-1 and high serum sP-sel levels in overweight and obese Subjects and their relation to platelet count | ||
| Aswan University Medical Journal | ||
| Article 4, Volume 4, Issue 3, December 2024, Pages 28-41 PDF (933.77 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/aumj.2024.312672.1133 | ||
| Authors | ||
| Amani Morad* 1; rania eid1; Mohamed Mohie2; asmaa muhammed1 | ||
| 1Department of Human Physiology, Faculty of Medicine, Aswan University | ||
| 2Department of Internal medicine, Faculty of medicine, Aswan University | ||
| Abstract | ||
| Obesity characterized by an elevated platelet count and hyper activation causing a pro-thrombotic state. Soluble P-selectin (sP-sel), an obesity-associated protein that enhences platelet activation, facilitates and augments thrombosis. Developmental endothelial locus-1(DEL-1) is an anti-inflammatory protein that enhances inflammation clearance; it inhibits platelet-monocyte aggregation hence thrombosis inhibition. However, serum levels of DEL-1 in obese and overweight subjects and their relation to platelet count and sP-sel have not been detected to date. Methods: 22 controls (Group A), 22 overweight subjects (Group B), and 22 obese subjects (Group C) were enrolled in this case-control study. Serum levels of PLC, MPV, RBCs, HB, WBCs, Lymphocyte count, sP-sel, and DEL-1 were measured. Results: levels of HB, DEL-1, and RBCs were lowest in group (C) and highest in group (A) with a statistically significant difference between these two groups. While, PLC,MPV, WBCs, lymphocyte count, and sP-sel levels were highest in group (C) and lowest in group (A). BMI, platelets, and WBCs count correlated positively with sP-sel and negatively with DEL-1 levels. sP-sel and DEL-1 showed a negative correlation with each other. Conclusion: Increased sP-sel and decreased DEL-1 levels in overweight and obese might have a role in raising thrombosis risk and inflammation in these subjects. | ||
| Keywords | ||
| Keywords: Developmental Endothelial Locus-1; Obesity; Platelet Count; Soluble P-selectin; Thrombosis | ||
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