Role of Fecal and Blood Markers in The Assessment of Severity of Ulcerative Colitis | ||
| Benha Medical Journal | ||
| Article 27, Volume 42, Issue 1, January 2025, Pages 280-292 PDF (873.34 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/bmfj.2024.316191.2181 | ||
| Authors | ||
| Ahmed Mohammad Abd El Mawla1; Nada Ahmed Ali Allam* 2; Ashraf Raafat Abouel Fetouh3; Osama Elbaz Elagroudy4; Mohammad Abd El Hamid Mohammad5 | ||
| 1Department of Hepatology, Gastroenterology and Infectious diseases, Faculty of Medicine, Benha University,Egypt. | ||
| 2M.B.B.CH of Hepatology, Gastroenterology, and Infectious Diseases Faculty of Medicine - Benha University | ||
| 3Educational Fellow of Tropical Medicine Mahala Hepatology Teaching Hospital | ||
| 4Prof. of Hematology and Clinical pathology Faculty of Medicine - Mansoura University | ||
| 5Professor of Hepatology, Gastroenterology and Infectious Diseases department Faculty of Medicine, Benha University | ||
| Abstract | ||
| Background: Ulcerative colitis (UC) is a chronic inflammatory bowel disease with varying severity, making accurate assessment critical for effective management, Fecal and blood markers have emerged as probable non-invasive tools for evaluating disease activity in UC. Aim: This study aimed to evaluate the effectiveness of combined fecal and blood markers in assessing UC severity. Methods: In a cross-sectional case-control study, 50 UC patients and 25 matched healthy controls were analyzed. Clinical data, along with albumin, complete blood count, C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), fecal calprotectin, and serum matrix metalloproteinase 9 (MMP-9) levels, were measured. Disease activity was assessed using the Mayo score and correlated with these biomarkers. Results: UC patients had significantly higher levels of ESR, CRP, and fecal calprotectin compared to controls (p < 0.001). MMP-9 levels were also significantly elevated in UC patients (1231.92 ± 612.93 ng/ml) versus controls (653.24 ± 265.17 ng/ml, p < 0.001). MMP-9 showed a positive correlation with bowel movements per day (r = 0.347, p = 0.013), bowel movements per night (r = 0.279, p = 0.050), SCCAI score (r = 0.408, p = 0.003), and CRP level (r = 0.281, p = 0.050). The optimal MMP-9 cut-off to distinguish UC patients from controls was > 471 ng/ml, with 78% sensitivity and 66% specificity. Conclusion: elevated serum MMP-9 and fecal calprotectin levels in UC patients correlate with disease activity and can be useful non-invasive markers for evaluating UC severity. | ||
| Keywords | ||
| Ulcerative colitis; fecal calprotectin; matrix metalloproteinase 9; disease severity; inflammatory marker | ||
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