Impact of Regular Hemodialysis on Short- and Long-Term Liver Function Evaluated by the Galactose Single Point Test
Rashad, A., Ahmad, O., Alkhrsawy, A., Ibrahim, E., Al Mestikawy, A. (2024). Impact of Regular Hemodialysis on Short- and Long-Term Liver Function Evaluated by the Galactose Single Point Test. EKB Journal Management System, 6(10), 5028-5032. doi: 10.21608/ijma.2024.320295.2031
Ayaa Mohamed Rashad; Osama Mohamad Ahmad; Amr Mohamed Abdelhady Alkhrsawy; El Sayed Abouzid Ibrahim; Amr Al Mestikawy. "Impact of Regular Hemodialysis on Short- and Long-Term Liver Function Evaluated by the Galactose Single Point Test". EKB Journal Management System, 6, 10, 2024, 5028-5032. doi: 10.21608/ijma.2024.320295.2031
Rashad, A., Ahmad, O., Alkhrsawy, A., Ibrahim, E., Al Mestikawy, A. (2024). 'Impact of Regular Hemodialysis on Short- and Long-Term Liver Function Evaluated by the Galactose Single Point Test', EKB Journal Management System, 6(10), pp. 5028-5032. doi: 10.21608/ijma.2024.320295.2031
Rashad, A., Ahmad, O., Alkhrsawy, A., Ibrahim, E., Al Mestikawy, A. Impact of Regular Hemodialysis on Short- and Long-Term Liver Function Evaluated by the Galactose Single Point Test. EKB Journal Management System, 2024; 6(10): 5028-5032. doi: 10.21608/ijma.2024.320295.2031

Impact of Regular Hemodialysis on Short- and Long-Term Liver Function Evaluated by the Galactose Single Point Test

International Journal of Medical Arts
Article 14, Volume 6, Issue 10, October 2024, Pages 5028-5032    PDF (1.61 M)
Document Type: Original Article
DOI: 10.21608/ijma.2024.320295.2031
Authors
Ayaa Mohamed Rashad* 1; Osama Mohamad Ahmad1; Amr Mohamed Abdelhady Alkhrsawy2; El Sayed Abouzid Ibrahim1; Amr Al Mestikawy3
1Department of Internal Medicine, Damietta Faculty of Medicine, Al-Azhar University, Damietta, Egypt.
2Department of Clinical Pathology, Damietta Faculty of Medicine, Al-Azhar University, Damietta, Egypt.
3Department of Internal Medicine, Faculty of Medicine, Al-Azhar University, Cairo, Egypt.
Abstract
Background: Liver illness significantly exacerbates the advancement of end-stage renal disease [ESRD]. Patients on long-term maintenance hemodialysis may experience enhanced liver function. The galactose single point [GSP] test is a novel technique for evaluating residual liver function.
Aim of the study: The study aims to assess the influence of regular hemodialysis on liver function, as measured by the galactose single-point test.
Patients and Methods: This prospective cohort study involved recruiting 80 patients on regular dialysis from the hemodialysis unit of the Internal Medicine department at Al-Azhar University Hospital, New Damietta, who met our selection criteria for six months.
Results: We found a powerful negative correlation between GSP and months of dialysis; significant negative correlations are observed between hemodialysis duration and both post-dialysis GSP and predialysis GSP, indicating that longer hemodialysis duration is associated with lower levels of GSP before and after dialysis.
Conclusion: Patients undergoing long-term hemodialysis maintenance observe a positive enhancement in liver functionality. Galactose metabolism relies on both liver blood flow and hepatic functional mass. It is possible that after hemodialysis [HD], there is a modest increase in blood flow to the liver, potentially leading to enhanced liver function, as observed in the GSP test
Keywords
Galactose Single Point test; End-Stage Renal Disease, Hemodialysis; Liver Function
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