Serum Interleukin 18 and NLRP3 in patients with Alopecia Areata | ||
| Benha Medical Journal | ||
| Article 25, Volume 42, Issue 1, January 2025, Pages 256-262 PDF (823.38 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/bmfj.2024.315109.2176 | ||
| Authors | ||
| Salma AwadAllah Al Yamani1; Asmaa Mohamed Al Refaei2; Eman Mohamed Hassan3; Nehad Ahmed Fouad4; Karem Taha khalil* 5 | ||
| 1M.B.B.Ch, Faculty of Medicine, Al-Azhar University | ||
| 2Dermatology, Venereology and Andrology department, Faculty of Medicine – Benha University,Egypt | ||
| 3Dermatology, Venereology and Andrology department, Faculty of Medicine, Benha University,Egypt | ||
| 4Microbiology and Immunology department, Faculty of Medicine, Benha University | ||
| 5DERMATOLOGY ANDROLOGY DEPARTMENT FACULTY OF MEDICINE BENHA UNIVERSITY EGYPT | ||
| Abstract | ||
| Background: Alopecia areata (AA) is a persistent hair follicle inflammatory condition with T lymphocyte invasion. Interleukin-18 (IL-18) and inflammatory proteins such as NOD-like receptor family pyrin domain containing 3 (NLRP3) have been connected with several inflammatory and autoimmune skin conditions. Objectives: To evaluate serum IL-18 and NLRP3 in patients with AA. Materials and methods: This case-control study comprised 50 patients with AA and 50 normal, healthy persons of comparable age and sex as a control group. Severity of AA was evaluated using the SALT score. ELISA kits were used to determine serum IL-18 and NLRP3 levels. Results: Serum IL-18 and NLRP3 levels were considerably greater in patients vs. controls (P= 0.01, | ||
| Keywords | ||
| Interleukin 18; NLRP3; Alopecia areata | ||
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