Serum Interleukin 18 and NLRP3 in patients with Alopecia Areata

Al Yamani, Salma AwadAllah; Al Refaei, Asmaa Mohamed; Hassan, Eman Mohamed; Fouad, Nehad Ahmed; khalil, Karem Taha

doi:10.21608/bmfj.2024.315109.2176

	Serum Interleukin 18 and NLRP3 in patients with Alopecia Areata
Benha Medical Journal
Article 25, Volume 42, Issue 1, January 2025, Page 256-262 PDF (823.38 K)
Document Type: Original Article
DOI: 10.21608/bmfj.2024.315109.2176
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Authors
Salma AwadAllah Al Yamani¹; Asmaa Mohamed Al Refaei²; Eman Mohamed Hassan ³; Nehad Ahmed Fouad⁴; Karem Taha khalil ⁵
¹M.B.B.Ch, Faculty of Medicine, Al-Azhar University
²Dermatology, Venereology and Andrology department, Faculty of Medicine – Benha University,Egypt
³Dermatology, Venereology and Andrology department, Faculty of Medicine, Benha University,Egypt
⁴Microbiology and Immunology department, Faculty of Medicine, Benha University
⁵DERMATOLOGY ANDROLOGY DEPARTMENT FACULTY OF MEDICINE BENHA UNIVERSITY EGYPT
Abstract
Background: Alopecia areata (AA) is a persistent hair follicle inflammatory condition with T lymphocyte invasion. Interleukin-18 (IL-18) and inflammatory proteins such as NOD-like receptor family pyrin domain containing 3 (NLRP3) have been connected with several inflammatory and autoimmune skin conditions. Objectives: To evaluate serum IL-18 and NLRP3 in patients with AA. Materials and methods: This case-control study comprised 50 patients with AA and 50 normal, healthy persons of comparable age and sex as a control group. Severity of AA was evaluated using the SALT score. ELISA kits were used to determine serum IL-18 and NLRP3 levels. Results: Serum IL-18 and NLRP3 levels were considerably greater in patients vs. controls (P= 0.01,
Keywords
Interleukin 18; NLRP3; Alopecia areata


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