The antibacterial activity of Hibiscus rosa-sinensis extract on methicillin-resistant Staphylococcus aureus and multi-drug resistance Acinetobacter baumanii Isolates. | ||||
| Microbes and Infectious Diseases | ||||
| Articles in Press, Accepted Manuscript, Available Online from 08 October 2024 | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/mid.2024.324805.2257 | ||||
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| Authors | ||||
Safaa Mohammed Abdel-Rahman1; Reham Ali Ahmed Khalifa 1; Nashwa almaabady2; Amany Raafat Maher  1
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| 1Department of Medical Microbiology and Immunology, Faculty of Medicine, Ain Shams University, Cairo, Egypt | ||||
| 2Microbiology specialist in microbiology department in National Bank of Egypt Hospital | ||||
| Abstract | ||||
| Background: Increasing untreatable infections caused by multi-drug resistant (MDR) bacteria necessitate development of new antibacterial agents. Natural plant extracts considered an appropriate alternative to antibiotics. Studies have shown that Hibiscus rosa-sinensis (H.rosa-sinensis) extract has a wide antibacterial, antipyretic, anti inflammatory and antioxidant effects. Aim: To detect the antibacterial activity and potential synergistic effect of H.rosa-sinensis extract on Methicillin-Resistant Staphylococcus aureus (MRSA) and MDR Acinetobacter baumannii (A. baumanii)isolates. Methods: The present study was done on 30 MRSA and 30 MDR A. baumanii isolates. For each bacterial isolate antimicrobial susceptibility was done before and after addition of H.rosa-sinensis extract to the tested antibiotics. The synergestic effect of H. rosa-sinensis extract addition was detected by the percent of change in the zone of inhibition for the combined H.rosa-sinensis extract/antibiotic disc in comparison to the antibiotic disc alone. Results: There was statistically significant increase in zone of inhibition of all used antibiotics against tested bacterial isolates after H.rosa-sinensis extract addition.For MRSA the synergestic effect of H.rosa-sinensis extract was detected in 53.3% of tested MRSA isolates for oxacillin and 3.3 % for vancomycin. For MDR A.baumanii, the synergestic effect of H.rosa-sinensis was detected in 86.7%of tested MDR A. baumanii isolates in cefoxitin and 80% in cefotaxime, cefazidime, cefepime and ciprofloxacin. Conclusion: H.rosa-sinensis is a natural extract that showed marked antibacterial and synergistic effect on MRSA and MDR A.baumanii isolates. H.rosa-sinensis extract/antibiotic combination is a potential alternative to the conventional antibiotics with less side effect. | ||||
| Keywords | ||||
| Hibiscus Rosa-Sinensis; Methicillin-Resistant Staphylococcus Aureus; Acinetobacter Baumanii Isolates | ||||
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