Green Synthesis, Molecular Docking Study and Antimicrobial Activity of Novel Metal Complexes Containing triazin-4-yl naphthalen-2-ol Moiety
Hassan, A., Heakal, B., khamis, H., Marzouk, E., El-Shahat, E., Younis, A. (2025). Green Synthesis, Molecular Docking Study and Antimicrobial Activity of Novel Metal Complexes Containing triazin-4-yl naphthalen-2-ol Moiety. EKB Journal Management System, 68(6), 247-262. doi: 10.21608/ejchem.2024.309360.10131
Ali Hassan; Bassem Heakal; hamdy khamis; Emad Marzouk; El-Sayed El-Shahat; Ahmed Younis. "Green Synthesis, Molecular Docking Study and Antimicrobial Activity of Novel Metal Complexes Containing triazin-4-yl naphthalen-2-ol Moiety". EKB Journal Management System, 68, 6, 2025, 247-262. doi: 10.21608/ejchem.2024.309360.10131
Hassan, A., Heakal, B., khamis, H., Marzouk, E., El-Shahat, E., Younis, A. (2025). 'Green Synthesis, Molecular Docking Study and Antimicrobial Activity of Novel Metal Complexes Containing triazin-4-yl naphthalen-2-ol Moiety', EKB Journal Management System, 68(6), pp. 247-262. doi: 10.21608/ejchem.2024.309360.10131
Hassan, A., Heakal, B., khamis, H., Marzouk, E., El-Shahat, E., Younis, A. Green Synthesis, Molecular Docking Study and Antimicrobial Activity of Novel Metal Complexes Containing triazin-4-yl naphthalen-2-ol Moiety. EKB Journal Management System, 2025; 68(6): 247-262. doi: 10.21608/ejchem.2024.309360.10131

Green Synthesis, Molecular Docking Study and Antimicrobial Activity of Novel Metal Complexes Containing triazin-4-yl naphthalen-2-ol Moiety

Egyptian Journal of Chemistry
Volume 68, Issue 6, June 2025, Page 247-262  XML PDF (1.47 MB)
Document Type: Original Article
DOI: 10.21608/ejchem.2024.309360.10131
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Authors
Ali Hassanorcid 1; Bassem Heakal2; hamdy khamis3; Emad Marzouk4; El-Sayed El-Shahat5; Ahmed Younis email 6
1Al Azhar University
2Research Laboratory, Cairo Oil Refining Company, Mostorod, Kaliobia, Egypt
3Chemistry Department Faculty of Science, Al-Azhar University, Nasr City
4Researcher chemist, Pwt International Company, Alexandria, Egypt.
54. Department of sustainable development of environment and its project management, environmental studies and research institute, sadat city university, sadat city, menofiya, Egypt
6National Research Centre
Abstract
This study focuses on the preparation of 1-(2-amino-4,10-dihydrobenzo[4,5]imidazo[1,2-a][1,3,5]triazin-4- yl)naphthalen-2-ol (ligand) and its metal complexes of Mn (II), Co (II), Ni (II), Cu (II) and Zn (II) using microwave irradiation as a green chemistry approach. The compounds were synthesized and examined by using various techniques, including elemental analyses FT-IR, UV-Vis, 1HNMR, 13CNMR, mass spectra and thermal properties to confirm their structural formula. The magnetic studies at room temperature for metal complexes were performed by Jouy method, but studying of Mn (II) and Co (II) complexes at different temperatures by Faraday method. Gaussian 09 W; DFT B3LYP method was used to adjust the geometries of the ligand and its Mn (II), Co (II), Ni (II), Cu (II) and Zn (II) complexes. Molecular docking study is achieved for All prepared compounds against 1BQB protein. Mn (II) complex exhibits the best energy score with value= -8.4471 Kcal mol- 1. The ligand and some metal complexes were tested for antimicrobial activity.
Keywords
Green Chemistry; Microwave; Metal Complexes; Molecular Docking and Antimicrobial Activity
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