Clinical and Histological Efficacy of Nanofat Grafting in the Healing Process of Chronic Ulcers | ||||
| The Egyptian Journal of Plastic and Reconstructive Surgery | ||||
| Article 11, Volume 48, Issue 4, October 2024, Page 327-334 PDF (1.59 MB) | ||||
| Document Type: Research article | ||||
| DOI: 10.21608/ejprs.2024.385113 | ||||
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| Authors | ||||
| Sherif Mohamed Saif Eldeinin Elsayed* 1; HESHAM HELAL1; Mohamed Abdelmohsen Ghanem1; Ebrahim Mohamed Amin Abdelgawad* 1; Jolly Mounir William Labib* 2 | ||||
| 1The Departments of Plastic, Burn & Maxillofacial Surgery, Faculty of Medicine, Ain Shams University | ||||
| 2The Departments of Histology & Cell Biology, Faculty of Medicine, Ain Shams University | ||||
| Abstract | ||||
| Background: Chronic ulcers have many bad impacts and are becoming an economic burden. Nanofat is rich origin of fatty-derived stem cells and different precursor cells. This work aimed to assess efficacy of nanofat injection in chronic ulcers and evaluating its effect on the healing process. Objective: Evaluation of the efficacy of non-fat graft injection in the healing process of chronic ulcers. Methods: This prospective randomized controlled study was carried out on 20 patients of both sexes aged between 18 - 60 years old with no co-morbidities. We included patients with chronic upper or lower extremity post-traumatic ulcers of 5cm maximum diameter with no healing on conventional dressing for at least 3 months. Patients were randomly divided into two equal groups: Group A (study group) was scheduled for nanofat injection and Group B (control group) with conventional dressing with no plan for surgical intervention. Results: Vascularity, pigmentation, pliability and height were significantly improved in group A than group B. Time frame for complete healing was significantly delayed in group < br />B than that of group A (median time for complete healing was 16.5 weeks and 3 weeks respectively). Patient satisfaction was significantly increased in group A than in group B. Skin biopsies showed that the epidermal thickness, dermal area % of collagen bundles and elastic fibres and the number of epidermal and dermal proliferating cell nuclei were significantly increased while the inflammatory cell count was markedly decreased in group A compared to ulcers of group B. Conclusions: Nanofat grafting may be a promising treatment option for patients with traumatic ulcers, as it can improve wound healing outcomes and patient satisfaction | ||||
| References | ||||
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