Serum biomarkers in Alzheimer’s disease | ||||
| Zagazig University Medical Journal | ||||
| Article 38, Volume 30, Issue 9, December 2024, Page 4662-4666 PDF (858.51 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/zumj.2024.314755.3535 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
mohamed hamdy ismail  1; ahmad sallam2; Nancy Abdelhamid Mohammad3
| ||||
| 1neurology | ||||
| 2clinicalpathology department | ||||
| 3Faculty of medicine, neurology department | ||||
| Abstract | ||||
| Abstract Background: AD is manifested by a gradually increasing impairment in cognitive functions and neurononal and synaptic loss with presence of senile plaques. Vitamin D has a function in neurotrophy, neurotransmission, neuroprotection, and neuroplasticity, its deficiency share in the pathogenesis of dementia and AD development. Serum albumin is an important human plasma protein and considered as a vital way for amyloid β declaration system as it binds from about 90% to 95% of the amyloid β in the blood. The goal of this work is to detect if there is a relationship between vitamin D, serum albumin levels in correlation with serum AB and the possibility of AD occurrence. Methods: 64 individuals ,32 patients with dementia and 32 healthy individuals, they were subjected to complete general and neurological examination ,Dementia Severity Rating Scale, MRI brain ,serum vit D ,albumin and AB levels. Results: There is a statistically significance between patients and control groups concerning age, AB42, MMSE, DSRS, serum albumin, and vitamin D. A statistically significant negative correlation between vitamin D and all of age, AB42, and DSRS were found. There is positive correlation between vitamin D and plasma albumin and MMSE. Also there is a positive correlation between plasma albumin and all of vitamin D and MMSE was detected. There is a negative correlation between AB42 and MMSE and statistically positive correlation between AB42 and DSRS. Conclusion: Low serum albumin and vitamin D levels possibly will increase the possibility of AD dementia. | ||||
| Keywords | ||||
| Keywords: AD; albumin; vitamin D; AB protein; Dementia | ||||
|
Statistics Article View: 1,456 PDF Download: 75 |
||||
