Serum biomarkers in Alzheimer’s disease | ||
| Zagazig University Medical Journal | ||
| Article 38, Volume 30, Issue 9, December 2024, Pages 4662-4666 PDF (858.51 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/zumj.2024.314755.3535 | ||
| Authors | ||
| mohamed hamdy ismail* 1; ahmad sallam2; Nancy Abdelhamid Mohammad3 | ||
| 1neurology | ||
| 2clinicalpathology department | ||
| 3Faculty of medicine, neurology department | ||
| Abstract | ||
| Abstract Background: AD is manifested by a gradually increasing impairment in cognitive functions and neurononal and synaptic loss with presence of senile plaques. Vitamin D has a function in neurotrophy, neurotransmission, neuroprotection, and neuroplasticity, its deficiency share in the pathogenesis of dementia and AD development. Serum albumin is an important human plasma protein and considered as a vital way for amyloid β declaration system as it binds from about 90% to 95% of the amyloid β in the blood. The goal of this work is to detect if there is a relationship between vitamin D, serum albumin levels in correlation with serum AB and the possibility of AD occurrence. Methods: 64 individuals ,32 patients with dementia and 32 healthy individuals, they were subjected to complete general and neurological examination ,Dementia Severity Rating Scale, MRI brain ,serum vit D ,albumin and AB levels. Results: There is a statistically significance between patients and control groups concerning age, AB42, MMSE, DSRS, serum albumin, and vitamin D. A statistically significant negative correlation between vitamin D and all of age, AB42, and DSRS were found. There is positive correlation between vitamin D and plasma albumin and MMSE. Also there is a positive correlation between plasma albumin and all of vitamin D and MMSE was detected. There is a negative correlation between AB42 and MMSE and statistically positive correlation between AB42 and DSRS. Conclusion: Low serum albumin and vitamin D levels possibly will increase the possibility of AD dementia. | ||
| Keywords | ||
| Keywords: AD; albumin; vitamin D; AB protein; Dementia | ||
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