Apoptosis and ovarian follicular atresia | ||||
| Veterinary Medical Journal (Giza) | ||||
| Volume 61, Issue 4, October 2015, Page 95-120 PDF (7.59 MB) | ||||
| DOI: 10.21608/vmjg.2015.385490 | ||||
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| Authors | ||||
| El-Shafey M* ; Mousa G; Tony M | ||||
| Department of Cytology and Histology, Faculty of Veterinary Medicine, Cairo University | ||||
| Abstract | ||||
| Programmed cell death "apoptosis" generally Characterized by distinct Morphological characteristics and energy dependent biochemical mechanisms. Apoptosis is considered a vital component of various processes including normal cell turnover, proper development and functioning of the immune system hormone-dependent atrophy, embryonic development and chemical-induced cell death. Inappropriate apoptosis (either too little or too much) is a factor in many human conditions Including neurodegenerative diseases. ischemic damage, autoimmune disorders and many types of cancer. The mechanisms responsible for germ cell depletion from the Ovary, either directly during the perinatal period or indirectly via follicular atresia during postnatal life, are dependent upon the activation of physiological cell death mechanisms, this accomplished via activation of a ‘universal’ pathway of cellular suicide Involving altered expression of 2 conserved cohort of genes. The goal of this review is to provide an overview of current knowledge on apoptosis including morphology, biochemistry, its role in health and disease, detection methods, and a discussion of its alternative forms of apoptosis. The identity of the hormonal and intracellular effectors responsible for the coordination of life and death decisions made by ovarian cells during development as well as the biological and clinical implications of gene-directed cell death in the ovary are explored in this review. | ||||
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