Impact of two Egyptian scorpion venoms on blood biochemistry during rat colon carcinogenesis

Radwan, Sara Osama Ibrahim Ali; Salim, Elsayed; Salama, Wesam Mohamed

doi:10.21608/djs.2024.317340.1187

	Impact of two Egyptian scorpion venoms on blood biochemistry during rat colon carcinogenesis
Delta Journal of Science
Volume 49, Issue 1, September 2024, Page 54-67 PDF (542.53 K)
Document Type: Research and Reference
DOI: 10.21608/djs.2024.317340.1187
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Authors
Sara Osama Ibrahim Ali Radwan ¹; Elsayed Salim ²; Wesam Mohamed Salama³
¹Zoology department, Faculty of Science, Tanta University, Egypt
²Zoology Department, Research Lab. for Molecular Carcinogenesis, Faculty of Science, Tanta University
³Faculty of Science-Zoology department
Abstract
The potential efficacy of two Egyptian scorpion species venoms, Leiurus quinquestratus and Androctonus bicolor was assessed in relation to hematological and biochemical parameters during the stages of chemically induced rat colon carcinogenesis. Fifty-five, 6-7-week-old male Sprague-Dawley rats weighing 120-125 gram were randomly divided into four groups: As a normal control, group 1 (10 rats) injected subcutaneous (s.c.) and intraperitoneal (i.p.) with saline only. From week 1 to week 4, groups 2, 3, and 4 received 1,2-dimethylhydrazine (40mg/kg/bw) weekly through s.c. injections. Groups 3 and 4 (15 rats per group) received i.p. injections of 1/20 of LD₅₀ from either L. quinquestratus (LQV) or A. bicolor (ABV) venoms from week 5 until the end of the experiment after 16 weeks. Rats were sacrificed following a 16-week experiment. Plasma and sera were collected from each rat's abdominal aorta. Significant alterations were observed in the hematological and biochemical liver and kidney parameters, in rats in treated groups administered (LQV) or (ABV) venoms. To sum up, the use of venoms isolated from L. quinquestratus or A. bicolor enhanced biochemical and hematological parameters during the colon carcinogenesis process.
Keywords
Scorpion venoms; Rats; DMH; Colorectal cancer; Blood biochemistry


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