The distribution of virulence genes and their correlation with antibiotic resistance of Klebsiella pneumoniae isolates in Ramadi city, Iraq | ||||
| Microbes and Infectious Diseases | ||||
| Articles in Press, Accepted Manuscript, Available Online from 13 October 2024 | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/mid.2024.317885.2197 | ||||
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| Authors | ||||
Mohammed RAdhi Mohaisen   1, 2; Karama T. A. Al-Taee1; Noor N. Al-Hayani3
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| 1Department of Basic Sciences, College of Dentistry, University of Anbar, Ramadi, Iraq. | ||||
| 2Department of Clinical Infection, Microbiology and Immunology, Institute of Infection, Veterinary, and Ecological Sciences, Faculty of Health and Life Sciences, University of Liverpool, Liverpool, L69 7TX, United Kingdom | ||||
| 3Microbiology Department, College of Medicine, University of Anbar, Ramadi, Iraq | ||||
| Abstract | ||||
| Klebsiella pneumoniae causes significant infections in neonate patients ranging from urinary tract infections to severe life-threatening meningitis. The severity of resulted diseases belongs to the virulence factors utilized by the bacteria to perform its infections and/or the bacterial antibiotic resistance due to abuse of antibiotic dosages. Aims: The aim of the study is to investigate the correlation between the Klebsiella pneumonia virulence genes, particularly rmpA gene, aerobactin gene, and colibactin gene, and the bacterial isolates' antibiotic resistance patterns. Methods: the study included 25 strains of K Pneumonaie, each isolate is subjected to string test, antibiotic susceptibility by VITEK2 system , three convential PCR tests to detect the distribution of three important Klebsiella pneumoniae virulence genes among these strains isolated from neonate patients. Results: The results showed a significant correlation between the presence of the virulence gene rmpA and the bacterial isolates’ antibiotic resistance ability, while a negative relationship was defined between the aerobactin and colibactin genes, the antibiotic resistance pattern of the bacterial isolates.Conclusion: There was a correlation between the presence of some important virulence genes and the ability of bacteria to resist antibiotic drugs. | ||||
| Keywords | ||||
| Multidrug resistance infections; neonates; sepsis; urinary tract infections and chest infection | ||||
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