SPANLASTICS: A Unique Formulation Strategy in The Delivery of Pharmaceuticals-Carbapenems as a Model.

Ahmed Mousa, Shadwa; Qelliny, Milad Reda; Ibrahem, Reham Ali; Hadiya, Safy; Sarhan, Hatem A.; Mady, Fatma Mohammed

doi:10.21608/jabps.2024.298914.1221

	SPANLASTICS: A Unique Formulation Strategy in The Delivery of Pharmaceuticals-Carbapenems as a Model.
Journal of Advanced Biomedical and Pharmaceutical Sciences
Article 1, Volume 7, Issue 4, October 2024, Page 117-125 PDF (507.5 K)
Document Type: Review Articles
DOI: 10.21608/jabps.2024.298914.1221
View on SCiNiTO
Authors
Shadwa Ahmed Mousa ¹; Milad Reda Qelliny ²; Reham Ali Ibrahem³; Safy Hadiya⁴; Hatem A. Sarhan³; Fatma Mohammed Mady ⁵
¹Department of Pharmaceutics, Faculty of Pharmacy, Minia University, 61519 Minia, Egypt. Department of Pharmaceutics, Faculty of Pharmacy, Merit University Egypt (MUE), Sohag, Egypt.
²Pharmaceutics Department, Faculty of Pharmacy, Minia University, 61519 Minia, Egypt.
³Department of Pharmaceutics, Faculty of Pharmacy, Minia University, 61519 Minia, Egypt.
⁴Assuit International Center of Nanomedicine, Al-Rajhy Liver Hospital, Assuit University, Assuit, 71515, Egypt.
⁵Pharmaceutics Department, Faculty Of Pharmacy, Minia University, 61519 Minia, Egypt.
Abstract
Drug delivery systems based on nanotechnology have been significant in surpassing the challenges associated with traditional dose forms. A promising drug delivery vehicle is spanlastics, an elastic nanovesicle that can transport a variety of drug compounds. Spanlastics have shown an increasing amount of interest in various forms of administrative pathways. They may squeeze themselves through skin pores because they are elastic and malleable, making them ideal for transdermal delivery. Non-ionic surfactants or mixtures of surfactants make up spanlastics. Numerous studies have demonstrated how spanlastics greatly improve drug toxicity, drug bioavailability, and therapeutic efficacy. Our future goal is to evaluate the spanlastic-encapsulated carbapenem's antibacterial and anti-biofilm characteristics. Following the isolation of Staphylococcus epidermidis isolates and the assessment of their microbiological sensitivity, the plate microtiter test was employed to investigate their capacity to form biofilms.
Keywords
Nanoparticles; Spanlastics; Spans; Edge activators; Carbapenems


Statistics Article View: 372 PDF Download: 700