Comparative Histological and Immunohistochemical Study on The Effect of Curcumin and Atorvastatin in Induced Atherosclerosis in Aorta and Cardiac Muscle of Male Rabbits | ||
| The Egyptian Journal of Hospital Medicine | ||
| Article 17, Volume 76, Issue 2, July 2019, Pages 3500-3515 PDF (1.11 M) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/ejhm.2019.38653 | ||
| Authors | ||
| Sheriff Aly Saleh1; Gamal Soliman Algharabawy1; Mohamed Ghazy Attia Hablas* 2 | ||
| 1Department of Histology, Faculty of Medicine, Al-Azhar University, Cairo, Egypt | ||
| 2Department of Histology, Faculty of Medicine, Al-Azhar University, Assiut, Egypt | ||
| Abstract | ||
| Background: curcumin has many pharmacological effects including antioxidant, anti-inflammation, eliminating free radicals, anti-tumor, lipid regulation and anti-coagulation. Objectives: to compare the histological effects of curcumin and atorvastatin in experimental induced atherosclerosis in the rabbit’s aorta and heart. Subjects and Methodology: thoracic aorta sections were prepared and stained by Hx&E, orcein, Masson's trichrome and immuonohistochemical staning using CD34. Cardiac sections were prepared and stained by Hx&E, Masson's trichrome stain and immuonohistochemical staning using troponin T. Morphometrical study included, the thickness of both tunica intima and media of thoracic aorta , area % of the elastic fibers contents of both tunica intima and media in thorathic aorta, and the area %of the immune reaction of CD34 in thoracic aorta . Results: the atherosclerotic group showed a significant increase in the thickness of both tunicae intima& media when compared with the control group. There was a significant decrease in elastic fibers content and significant increase in the mean area % of the immune reaction of CD34 versus control. In atorvastatin treated group: there was a significant increase in comparison to control group, while there was a significant decrease in comparison to atherosclerotic group. There was significant decrease in elastic fibers content and significant increase in the mean area % of the immune reaction of CD34 in comparison to control group. In curcumin treated group: the thickness of both tunica intima and media showed a significant increase in comparison to control group. Conclusion: curcumin has potential role in treatment of atherosclerosis and myocardial infarction. | ||
| Keywords | ||
| Atherosclerosis; Atorvastatin; Curcumin; Aorta; cardiac muscle | ||
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