Evaluation of isosorbide dinitrate versus misoprostol in management of second trimester missed abortion | ||||
| Zagazig University Medical Journal | ||||
| Volume 31, Issue 1, January 2025, Page 45-53 PDF (842.17 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/zumj.2024.326717.3624 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
Ahmed Abd Ellatief Mohammed  1; Amr Kamel El Fayomy2; Hala Sherif Elsayed 3; Wafaa Mohammad Ibrahim3
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| 1Obstetrics & Gynecology Department, Faculty of Medicine, Zagazig University, Egypt | ||||
| 2Department, Obstetrics and Gynecology, Faculty of Medicine, Zagazig University, Egypt. | ||||
| 3Obstetrics & Gynecology Department, Faculty of Medicine, Zagazig University, Egypt | ||||
| Abstract | ||||
| Background: Cervical ripening prior to fetal expulsion may be induced by the metabolic activity of endogenous nitric oxide (NO) and the medical use of nitro vasodilatory medications such as isosorbide dinitrate. In order to manage second trimester missed abortions, we set out to compare the therapeutic efficacy and safety of isosorbide dinitrate versus misoprostol. Methods: This prospective, double-blind, clinical trial was conducted at the department of obstetrics & gynecology at Zagazig university hospitals, Sharkia, Egypt, on 70 women having missed abortion between the 14-20 weeks of gestation. Patients were divided into two groups: Group (1): 35 women with missed abortion gestational age (GA) (14-20) received isosorbide dinitrate 80 mg = 4 tab., n = 35) and Group (2): 35 women with missed abortion GA (14-20) received misoprostol (100 mcg = ½ tab, n = 35). Results: Both groups showed accepted success rate; Dinitrate success rate was 74.3% and Misoprostol success rate was 85.7% without any statistically significant difference between both groups. The symptoms of post-induction complications were comparable in both groups. Headache was the most frequent complication in dinitrate group 20% while abdominal pain was the most frequent complication in Misoprostol 8.6 %. Conclusion: The findings of this study can offer a valuable insight aimed to enhancing counselling and support for isosorbide dinitrate compared to misoprostol in management of second trimester abortion. However, Isosorbide dinitrate is associated with significant side effects more than misoprostol as tachycardia, hypotension. | ||||
| Keywords | ||||
| Isosorbide dinitrate; Misoprostol; Second trimester; Missed abortion | ||||
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