Synthesis, characterization, and antimicrobial evaluation of some novel Imidazo[1,2-c] pyrimidine derivatives | ||||
| Bulletin of Faculty of Science, Zagazig University | ||||
| Article 16, Volume 2024, Issue 3, October 2024, Page 178-185 PDF (1.14 MB) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/bfszu.2024.267543.1363 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
Wael Shehta1; Ahmed H. Moustafa2; Asmaa Masry   1; Samar M. Mohammed 3
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| 1chemistry department-faculty of science-Zagazig university | ||||
| 2Department of Chemistry, Faculty of Science, Zagazig University, Zagazig, Egypt. | ||||
| 3Chemistry Department, Faculty of Science, Zagazig University | ||||
| Abstract | ||||
| Due to chalcone compounds' diverse and intriguing bioactive characteristics, the present work recommends the production of several new chalcone derivatives, followed by spectral characterization utilizing various spectral techniques such as IR, NMR, and elemental analyses. In addition to, assessment the antimicrobial activity of imidazo[1,2-c] pyrimidine derivatives. All tested new chalcone compounds showed antibacterial activity against P. aeruginosa and B. subtilis, while only compounds (5a-d and 5f) displayed activity against E. coli. Furthermore, only compounds (5a-c, 5e and 5f) reduced the development of S. aureus. The compound 5f revealed significant antibacterial activity against S. aureus (87.5%), B. subtilis (82.61 %), P. aeruginosa (78.26%) and E. coli (64%), when compared to Ampicillin. On the other hand, the compounds (5a-d, 5e and 5f) showed antifungal activity against C. Albicans. Also, compounds (5a, 5b, 5c, 5d and 5f) displayed activity against A. flavus. A significant antifungal activity for compound 5b has been observed against C. Albicans (70.37%) and A. flavus (52%), when compared to Colitrima-zole. | ||||
| Keywords | ||||
| new chalcones; imidazo[1; 2-c] pyrimidine; antibacterial activity; antifungal activity | ||||
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