Very early onset versus pediatric onset inflammatory bowel disease: a prospective cohort analysis | ||||
| The Egyptian Journal of Pediatric Allergy and Immunology | ||||
| Volume 22, Issue 2, October 2024, Page 81-89 PDF (315.92 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/ejpa.2024.312936.1075 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
Radwa Mohamed Abd elsalam1; moustafa Abdel Aziz El-Hodhod2; Ahmed Mohamed Hamdy  3; Ola Hassan Nada4; Dina Abdel Hamid Nabhan swilem5
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| 1Pediatric department ain shams university Cairo egypt | ||||
| 2Pediatric department Ain shams university Cairo Egypt | ||||
| 3Pediatric department Ain shams university Cairo Egypt | ||||
| 4Pathology department Ain sham university Cairo Egypt | ||||
| 5Pediatric department Ain sham university Cairo Egypt | ||||
| Abstract | ||||
| Background: Inflammatory bowel disease (IBD) in the pediatric age group is divided into two categories: very early onset IBD (VEO-IBD) and pediatric IBD (PIBD). The goal of this study was to determine the difference between the two entities concerning disease presentation, severity and treatment response. Methods: We conducted an observational prospective study that involved 70 newly diagnosed children with IBD, diagnosed using modified Porto criteria and followed up over a period of one year (35 VEO-IBD and 35 PIBD). It was conducted at the Pediatric Gastroenterology and Endoscopy Unit at Ain Shams University. Recruited cases were subjected to clinical assessment, and laboratory investigations including stool tests, full blood counts, and inflammatory markers in addition to ileo-colonoscopy and esophagogastroduodenoscopy. They were assessed initially and at follow-up for a total duration of one year for disease activity, treatment response, and disease relapse. Results: Gender distribution was similar among both VEO-IBD and PIBD groups. Rural residence (p=0.048), positive family history (p= 0.010), oral ulcers (p=0.022) and perianal skin tags (p=0.066) were more frequent among patients with VEO-IBD. Colonoscopy showed deeper ulcers in VEO-IBD (25.7%) than in PIBD (2.9%). Regression analysis showed that younger age (p=0.032) and high disease severity scores (p=0.011) were the main determinants of steroid non-responsiveness. Conclusion: Young age and severity score were the most predictive risk factors for steroid unresponsiveness in pediatric IBD | ||||
| Keywords | ||||
| Paediatric Onset Inflammatory Bowel Disease; Very Early Onset Inflammatory Bowel Disease; ulcerative colitis | ||||
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