PROGESTERONE PRIMED STIMULATED CYCLES VERSUS FIXED ANTAGONIST PROTOCOL IN INTRACYTOPLASMIC SPERM INJECTION CYCLES
Darwish, E., Abdel-moneim, M., gaafar, S., Mohammad Fayez Othman, A. (2024). PROGESTERONE PRIMED STIMULATED CYCLES VERSUS FIXED ANTAGONIST PROTOCOL IN INTRACYTOPLASMIC SPERM INJECTION CYCLES. EKB Journal Management System, 6(4), 37-38. doi: 10.21608/alexpo.2024.328025.1969
Emad Darwish; Mohamed Abdel-moneim; sherif gaafar; Ahmad Yahia Mohammad Fayez Othman. "PROGESTERONE PRIMED STIMULATED CYCLES VERSUS FIXED ANTAGONIST PROTOCOL IN INTRACYTOPLASMIC SPERM INJECTION CYCLES". EKB Journal Management System, 6, 4, 2024, 37-38. doi: 10.21608/alexpo.2024.328025.1969
Darwish, E., Abdel-moneim, M., gaafar, S., Mohammad Fayez Othman, A. (2024). 'PROGESTERONE PRIMED STIMULATED CYCLES VERSUS FIXED ANTAGONIST PROTOCOL IN INTRACYTOPLASMIC SPERM INJECTION CYCLES', EKB Journal Management System, 6(4), pp. 37-38. doi: 10.21608/alexpo.2024.328025.1969
Darwish, E., Abdel-moneim, M., gaafar, S., Mohammad Fayez Othman, A. PROGESTERONE PRIMED STIMULATED CYCLES VERSUS FIXED ANTAGONIST PROTOCOL IN INTRACYTOPLASMIC SPERM INJECTION CYCLES. EKB Journal Management System, 2024; 6(4): 37-38. doi: 10.21608/alexpo.2024.328025.1969

PROGESTERONE PRIMED STIMULATED CYCLES VERSUS FIXED ANTAGONIST PROTOCOL IN INTRACYTOPLASMIC SPERM INJECTION CYCLES

ALEXMED ePosters
Article 1, Volume 6, Issue 4, September 2024, Pages 37-38
Document Type: Preliminary preprint short reports of original research
DOI: 10.21608/alexpo.2024.328025.1969
Authors
Emad Darwish1; Mohamed Abdel-moneim2; sherif gaafar3; Ahmad Yahia Mohammad Fayez Othman* 4
1Obstetrics and Gynecology Department, Faculty of Medicine, Alexandria University
2Department of Obstetrics and Gynecology, Alexandria Faculty of Medicine, Alexandria University
3ob/gyn, faculty of medicine, alexandria university
4Department Of Obstetrics & Gynecology, Faculty of Medicine, Alexandria University
Abstract
INTRODUCTION
To maximize the likelihood of a successful outcome, the procedures utilized for ovulation stimulation during assisted reproductive techniques (ART) attempt to retrieve the maximum number of oocytes. To prevent an early luteinizing hormone (LH) peak and ovulation before oocyte extraction, gonadotropin-stimulating hormone (GnRH) antagonists or agonists are frequently added. Available evidence suggests that progesterone-primed ovarian stimulation (PPOS) provides a similar number of oocytes retrieved and pregnancy rate per transfer compared with the GnRH antagonist protocol.

AIM OF THE WORK
This study aims to compare progesterone-primed stimulated cycles and fixed antagonist protocol in intracytoplasmic sperm injection (ICSI) procedures when applying the freeze-all and blastocyst transfer strategy. Primary aim: Clinical Pregnancy Rate at the first ET (Blastocyst).
Secondary aim: The mean metaphase of meiosis II (MII) retrieved oocytes, rate of fertilization, rate of blastocyst formation, average length of stimulation, and average gonadotropin dosage.

PATIENTS& METHODS
This prospective randomized controlled trial (RCT) included 2 groups of 180 women, (90 each); recruited from the infertility unit at El Shatby University Hospital in collaboration with private IVF centers in Alexandria. All patients were undergoing ICSI and frozen embryo transfer (FET). Patients were subjected to either; group I [Progesterone primed ovarian stimulation (PPOS)] or group II [Gonadotropin-releasing hormone antagonist (GnRH anta) protocol], through a random computerized allocation system; to compare between progesterone primed stimulated cycles and fixed antagonist protocol in intracytoplasmic sperm injection (ICSI) procedure when the freeze-all and blastocyst transfer strategy is applied.
Keywords
PROGESTERONE; VERSUS; ANTAGONIST
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